Laser Immunotherapy:Novel Modality to Treat Cancer through Specific Antitumor Immune Response  

作　　者：李晓松 陈伟 

机构地区：[1]Department of Oncology,the First Affiliated Hospital of Chinese PLA General Hospital [2]Department of Engineering and Physics,University of Central Oklahoma,Edmond

出　　处：《中国激光》2010年第11期2698-2702,共5页Chinese Journal of Lasers

基　　金：supported in part by the US National Institutes of Health(P20 PR016478 from the INBRE Program of the National Center for Research Resources)

摘　　要：Treatment of metastatic cancer remains a great challenge and needs novel approaches.Combining a selective photothermal therapy with an active immunological stimulation,laser immunotherapy(LIT) was developed to induce systemic immune responses through local intervention.LIT consists of three major components: a near-infrared laser,a light-absorbing agent,and an immunological stimulant.Its effect relies on two major interactions: a selective photothermal interaction and an active immunological stimulation.The selective photothermal interaction can reduce the tumor burden and at the same time release the tumor antigens,which can induce specific antitumor immune response.The expression of heat shock protein and the application of immunoadjuvant further enhance the host immunity.It has been proved in pre-clinical studies that LIT could not only eradicate treated local tumors but also regress and eliminate untreated metastases at distant sites.Moreover,LIT is well tolerated and has shown to have many advantages for cancer treatment compared with other traditional modalities.Treatment of metastatic cancer remains a great challenge and needs novel approaches.Combining a selective photothermal therapy with an active immunological stimulation,laser immunotherapy（LIT） was developed to induce systemic immune responses through local intervention.LIT consists of three major components： a near-infrared laser,a light-absorbing agent,and an immunological stimulant.Its effect relies on two major interactions： a selective photothermal interaction and an active immunological stimulation.The selective photothermal interaction can reduce the tumor burden and at the same time release the tumor antigens,which can induce specific antitumor immune response.The expression of heat shock protein and the application of immunoadjuvant further enhance the host immunity.It has been proved in pre-clinical studies that LIT could not only eradicate treated local tumors but also regress and eliminate untreated metastases at distant sites.Moreover,LIT is well tolerated and has shown to have many advantages for cancer treatment compared with other traditional modalities.

关 键 词：medical optics laser immunotherapy cancer treatment IMMUNOADJUVANT cancer vaccine glycated chitosan 

分 类 号：R730.57[医药卫生—肿瘤]