Δ-和Λ-[Ru(bpy)_2(HPIP)]^(2+)两种异构体对小牛胸腺DNA不同键合速率的CD光谱证明  

Observation of the Different Binding Rates of \| and \|\= \{\ \}\+\{2+\} with Calf Thymus DNA via CD Spectra

作　　者：刘劲刚[1,2,3] 叶保辉[1,2,3] 计亮年 田暄[1,2,3] 傅瑶红 

机构地区：[1]中山大学化学系 [2]兰州大学应用有机化学国家重点实验室 [3]上海有机化学研究所生命有机与天然产物国家重点实验室

出　　处：《高等学校化学学报》1999年第4期525-525,共1页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金;广东省基金

摘　　要：Ｗｉｌｓｏｎ［１］于１９９７年发表了关于ＤＮＡ导电性的评论性文章，介绍了各种学派的观点．争论焦点在于ＤＮＡ是否为导体．将两种配合物键合于ＤＮＡ作为接头，通过研究电子转移可确定ＤＮＡ是否为导线，其中配合物和ＤＮＡ键合模式是研究的关键．Ｂａｒｔｏｎ［２］...The complexes of \| and \|\{\ \}\+\{2+\}(bpy=2,2\|bipyridine, HPIP=2\|(2\|hydroxyphenyl)imidazo\{\ \}\ phenanthroline) were prepared and their racemic complex were dialysed against calf thymus DNA(CT\|DNA). During the course of dialysis with the solution stirring for 48 h, the CD signals of the dialyzate experience disappearing\|appearing\|disappearing. However, in the similar conditions except for not stirring, strong CD signals appeared. From the results obtained, several novel opinions were suggested. Firstly, the evidence of different binding rates of \| and \|enantiomers of polypyridyl ruthenium() complexes with CT\|DNA, the first example, was demonstrated. As for the dialysis experiment, binding of \|enantiomer is dynamically preferred for CT\|DNA. Secondly, the different binding rates may be deduced from different binding modes of the enantiomers.

关 键 词：钌配合物 DNA 电子转换 导电性 键合 

分 类 号：O614.821[理学—无机化学] Q523.03[理学—化学]