Synthesis of novel D-seco-taxoids derived from 1-deoxybaccatinⅥ  

作　　者：Jun Chao Shao Zhi Hua Ye Hai Xia Lin Dian Long Wang Na Han 

机构地区：[1]Department of Chemistry, Shanghai University, Shanghai 200444, China

出　　处：《Chinese Chemical Letters》2010年第11期1273-1276,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.30672506);Leading Academic Discipline Project of Shanghai Municipal Education Commission(No.J50102)

摘　　要：New D-seco-taxoids were synthesized from 1-deoxybaccatinⅥand their structures were confirmed by 1H NMR,13C NMR, ESIMS and X-ray crystallography.The key step of the synthesis involved the opening of the oxetane ring under acid and basic conditions in order to obtain new multidrug resistance（MDR） reversal agents and new synthetic precursors of paclitaxel analogues.New D-seco-taxoids were synthesized from 1-deoxybaccatinⅥand their structures were confirmed by 1H NMR,13C NMR, ESIMS and X-ray crystallography.The key step of the synthesis involved the opening of the oxetane ring under acid and basic conditions in order to obtain new multidrug resistance（MDR） reversal agents and new synthetic precursors of paclitaxel analogues.

关 键 词：TAXOIDS 1-DeoxybaccatinⅥ Oxetane ring PACLITAXEL 

分 类 号：O636.12[理学—高分子化学] TQ223.26[理学—化学]