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TAXOIDS: 作品数：21被引量：26H指数：3; 导出分析报告; 相关领域：理学医药卫生更多>>; 相关作者：项勇刘君崔京霞更多>>; 相关机构：中国科学院沈阳药科大学更多>>; 相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Chemical Research in Chinese Universities》《Chinese Journal of Structural Chemistry》更多>>; 相关基金：国家自然科学基金更多>>

The genomes of Taxus species unveil novel candidates in the biosynthesis of taxoids被引量：3: 《Molecular Plant》2021年第11期1773-1775,共3页Youjun Zhang Federico Scossa Alisdair R.Fernie; A.R.F.and Y.Z.thank the European Union's Horizon 2020 research and innovation program,project Planta SYST(SGA-CSA no.739582 under FPA no.664620)for supporting their research.; Taxaceae is the yew family of conifers and includes evergreen trees and small shrubs mainly distributed in Eurasia and North America.The genus of Taxus has attracted considerable attention since Monroe E.Wall and Mans...; 关键词：UNUSUAL Monro COMPOUND

Crystal Studies and Antitumor Activities of Novel D-seco-taxoids Derived from 1-Deoxybaccatin Ⅵ被引量：1: 《Chinese Journal of Structural Chemistry》2019年第9期1511-1518,共8页XIE Cheng-Hu WANG Dian-Long CUI Yong-Mei LIN Hai-Xia; supported by the National Natural Science Foundation of China(No.21272154 and 81202402); Two novel taxoids were synthesized from 1-deoxybaccatin Ⅵ and their crystal structures were determined by X-ray crystallographic techniques. The influences of oxetane ring on molecular conformations and bioactivity w...; 关键词：CRYSTAL structure CONFORMATION 1-deoxybaccatin Ⅵ OXETANE bioactivity

Synthesis of novel D-seco-taxoids derived from 1-deoxybaccatinⅥ被引量：1: 《Chinese Chemical Letters》2010年第11期1273-1276,共4页Jun Chao Shao Zhi Hua Ye Hai Xia Lin Dian Long Wang Na Han; the National Natural Science Foundation of China(No.30672506);Leading Academic Discipline Project of Shanghai Municipal Education Commission(No.J50102); New D-seco-taxoids were synthesized from 1-deoxybaccatinⅥand their structures were confirmed by 1H NMR,13C NMR, ESIMS and X-ray crystallography.The key step of the synthesis involved the opening of the oxetane ring u...; 关键词：TAXOIDS 1-DeoxybaccatinⅥ Oxetane ring PACLITAXEL

Biological Fingerprinting Analysis of Interaction Between Taxoids in Taxus and Microtubule Protein by Microdialysis Coupled with High-performance Liquid Chromatography/Mass Spectrometry for Screening Antimicrotubule Agents被引量：1: 《Chemical Research in Chinese Universities》2008年第4期411-419,共9页LEI Xiao-yuan KONG Liang SU Xing-ye GUO Ming ZOU Han-fa; the National Natural Science Foundation of China(No.90709021);Knowledge Innovation Program of Chi-nese Academy of Sciences(No.KJCX2.YW.HO9); Some natural products, such as traditional Chinese medicines（TCMs）, contain compounds with anticancer activity and have attracted a great interest in recent years as alternative anticancer therapies. A quick and con...; 关键词：Microdialysis/high-performance liquid chromatography（HPLC） Biological fingerprinting analysis TAXOIDS MICROTUBULE TAXUS

Modeling resistance index of taxoids to MCF-7 cell lines using ANN together with electrotopological state descriptors: 《Acta Pharmacologica Sinica》2008年第3期385-396,共12页Pei-pei DONG Yan-yan ZHANG Guang-bo GE Chun-zhi AI Yong LIU Ling YANG Chang-xiao LIU; Project supported by the National Natural Science Foundation of China （No 30640066 and 30630075）, and the Innovation Youth Foundation of Dalian Institute of Chemical Physics （No_ S200612）.; Aim： To develop an artificial neural network model for predicting the resistance index （RI） of taxoids. Methods： A dataset of 63 experimental data points were compiled from published studies and randomly subdivide...; 关键词：artificial neural network model TAXOIDS multidrug resistance resistance index electrotopological state indices principle component analysis quantitative structureactivity relationship

A New Taxoid from Leaves and Branches of Taxus chinensis: 《Chinese Chemical Letters》2004年第3期307-308,共2页FuShengWANG LiYanPENG YuZHAO QinShiZHAO KunGU HanDongSUN; A new taxoid, 2-deacetyl-2a, 14b-dihydroxybaccatin IV (1), was isolated from the leaves and branches of Taxus chinensis together with the known compound baccatin IV (2). The structure of the new compound was elucidat...; 关键词：TAXOIDS Taxus chinensis 2-deacetyl-2a 14b-dihydroxy-baccatin IV.

Structure identification for compound I separated and purified from taxoids-produced endophytic fungi (Alternaria. alternata var. taxi 1011): 《Journal of Forestry Research》2003年第3期217-220,共4页项勇刘君呂安国崔京霞; Endophytic fungi are widely found in almost all kinds of plants. Many endophytic fungi can produce some physio-logical active compounds, which are same to or analog to those isolated from their hosts. Producing physio...; 关键词：Alternaria. Alternata var. taxi 1011 TAXOIDS Separation Purification Structure identification

Taxotere resistance in SUIT Taxotere resistance in pancreatic carcinoma cell line SUIT 2 and its sublines被引量：7: 《World Journal of Gastroenterology》2001年第6期855-859,共5页Edgar Staren Takeshi lwamura HubertAppert JohnHoward; Supported in part by Phne-Poulenc Rorer Pharmaceuticals INC.; AIM: To investigate the specific mechanisms of intrinsic and acquired resistance to taxotere (TXT) in pancreatic adenocarcinoma (PAC). METHODS: MTT assay was used to detect the sensitivity of PAC cell line SUIT-2 and ...; 关键词：Drug Resistance Neoplasm TAXOIDS Antineoplastic Agents Phytogenic Carcinoma Humans Paclitaxel derivatives Pancreatic Neoplasms Research Support Non-U.S. Gov't Tumor Cells Cultured

Effects of Taxotere on invasive potential and multidrug resistance phenotype in pancreatic carcinoma cell line SUIT-2被引量：12: 《World Journal of Gastroenterology》2001年第1期143-148,共6页Edgar Staren Takeshi Iwamura Hubert Appert John Howard; Supported in part by phone-Poulenc Rorer Pharmaceuticals INC; INTRODUCTIONDevelopment of drug-resistance to chemotherapyand subsequent metastasis of tumor are primarilyresponsible for treatment failure and the death fromcancer. There have been many previous studies onthe relatio...; 关键词：Carcinoma Pancreatic Neoplasms TAXOIDS Antineoplastic Agents Phytogenic Biocompatible Materials Collagen Drug Combinations Drug Resistance Multiple Drug Resistance Neoplasm Fluorescent Dyes Humans In Vitro LAMININ Neoplasm Invasiveness P-Glycoprotein Paclitaxel derivatives Phenotype PROTEOGLYCANS RNA Neoplasm Research Support Non-U.S. Gov't Rhodamine 123 Tumor Cells Cultured

Four New Taxoids from the Barks of Taxus yunnanensis: 《Chinese Chemical Letters》2001年第1期63-66,共4页Sheng Hong LI Hong Jie ZHANG Ping YAO Han Dong SUN; supported by grants from the National Natural Science Foundation of China(3950081);the Young Academic and Technical Leader Raising Foundation of Yunnan Province(awarded toH-J.Z.);the Special Supported Biosc ience and Biotechnique Foundation of Academic Sinica(STZ-11).; From the barks of Taxus yunnanensis, a new paclitaxel-related compound, 7-xylosyl-taxol D (1), and three new 11(15-->1)-abeotaxoids, taxuyunnanines P-R (2-4) have been isolated. Their structures were determined on the...

TAXOIDS