Effects of Taxotere on invasive potential and multidrug resistance phenotype in pancreatic carcinoma cell line SUIT-2  

作　　者：Edgar Staren Takeshi Iwamura Hubert Appert John Howard 

机构地区：[1]Department of Surgery, Medical College of Ohio, Toledo, Ohio, USA [2]Department of Surgery, Miyazaki Medical College, Miyazaki, Japan

出　　处：《World Journal of Gastroenterology》2001年第1期143-148,共6页世界胃肠病学杂志（英文版）

基　　金：Supported in part by phone-Poulenc Rorer Pharmaceuticals INC

摘　　要：INTRODUCTIONDevelopment of drug-resistance to chemotherapyand subsequent metastasis of tumor are primarilyresponsible for treatment failure and the death fromcancer. There have been many previous studies onthe relationship between expression of multidrugresistance (MDR) phenotype P-glycoprotein (P-gp)and the malignant properties of tumors, but theresults are often conflicting[1-8]. The difference intumor types or MDR phenotype induced by specificagents might account for this discrepancy. Taxotere(TXT), a member of the family of taxanes, hasantitumor activity through its effect of promotingthe polymerization of tubulin[9,10].

关 键 词：Carcinoma Pancreatic Neoplasms TAXOIDS Antineoplastic Agents  Phytogenic Biocompatible Materials Collagen Drug Combinations Drug Resistance  Multiple Drug Resistance  Neoplasm Fluorescent Dyes Humans In Vitro LAMININ Neoplasm Invasiveness P-Glycoprotein Paclitaxel derivatives Phenotype PROTEOGLYCANS RNA  Neoplasm Research Support  Non-U.S. Gov't Rhodamine 123 Tumor Cells  Cultured 

分 类 号：R735.9[医药卫生—肿瘤]