PROTEOGLYCANS

作品数：20被引量：55H指数：5
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相关领域：医药卫生更多>>
相关作者：李轩史金辉更多>>
相关机构：天津市眼科医院中国医科大学附属第一医院苏州大学更多>>
相关期刊：《Chinese Journal of Traumatology》《Open Journal of Physical Chemistry》《World Journal of Gastroenterology》《World Journal of Clinical Oncology》更多>>
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Axonal growth inhibitors and their receptors in spinal cord injury:from biology to clinical translation被引量：4
《Neural Regeneration Research》2023年第12期2573-2581,共9页Sílvia Sousa Chambel Célia Duarte Cruz 
a Ph D fellowship by FCT-Fundacao para a Ciência Tecnologia (SFRH/BD/135868/2018)(to SSC)。
Axonal growth inhibitors are released during traumatic injuries to the adult mammalian central nervous system, including after spinal cord injury. These molecules accumulate at the injury site and form a highly inhibi...
关键词：chondroitin sulphate proteoglycans collapsin response mediator protein 2 inhibitory molecules leucine-rich repeat and Ig domain containing 1 leucocyte common antigen related myelin-associated glycoprotein neurite outgrowth inhibitor A Nogo receptor 1 Nogo receptor 3 oligodendrocyte myelin glycoprotein p75 neurotrophin receptor Plexin A2 Ras homolog family member A/Rho-associated protein kinase receptor protein tyrosine phosphataseσ repulsive guidance molecule A spinal cord injury tumour necrosis factor receptor superfamily member 19 
The contribution of proteoglycans to heterogeneity and temozolomide resistance of glioblastoma cells
《Journal of Cancer Metastasis and Treatment》2023年第1期431-444,共14页Sofia A.Nikitina Dmitry K.Sokolov Alexandra Y.Tsidulko Anastasia V.Strokotova Elizaveta Fasler Kan Elvira V.Grigorieva 
This work was supported by the Russian Science Foundation(Grant No.21-15-00285)in part of GR and HS biosynthesis;within the state assignment of Ministry of Science and Higher Education of the Russian Federation(theme No.122032200240-8)in part of GB cells characterization and PGs expression.
Aim:Heterogeneity of glioblastoma(GB)cells significantly contributes to tumor resistance against temozolomide(TMZ)and the development of disease relapse.Multiple molecular mechanisms are involved in this process,yet t...
关键词：Glioblastoma temozolomide resistance extracellular matrix PROTEOGLYCAN GLYCOSAMINOGLYCAN heparan sulfate chondroitin sulfate glucocorticoid receptor 
Proteoglycans and their functions in esophageal squamous cell carcinoma被引量：5
《World Journal of Clinical Oncology》2021年第7期507-521,共15页Yun Zhu Annie Lai Man Cheung 
Supported by Research Grants Council of the Hong Kong SAR,China,No.17111016 and No.17100819.
Esophageal squamous cell carcinoma(ESCC)is a highly malignant disease that has a poor prognosis.Its high lethality is mainly due to the lack of symptoms at early stages,which culminates in diagnosis at a late stage wh...
关键词：Esophageal squamous cell carcinoma PROTEOGLYCAN GLYCOSAMINOGLYCAN SERGLYCIN Extracellular matrix Biomarker 
Interaction of arterial proteoglycans with low density lipoproteins(LDLs):From theory to promising therapeutic approaches被引量：2
《Medicine in Novel Technology and Devices》2019年第3期1-8,共8页Hongyan Kang Jinyan Lu Jiali Yang Yubo Fan Xiaoyan Deng 
supported by Grants-in-Aid from the National Natural Science Foundation of China(No.31870940,11772036,11572028,11421202);National Key Research and Development Program in China(No.2017YFB0702501);the Fundamental Research Funds for the Central Universities.
Although atherosclerosis is a multifactorial process,proteoglycans mediated lipoprotein(LDL)retention at the subendothelial space is a necessary and sufficient event in provoking lesion initiation.Proteoglycans(PGs)ar...
关键词：PROTEOGLYCANS Low-density lipoprotein ATHEROSCLEROSIS Endothelial glycocalyx 
Manifestation of Pathological States of Numerous Diseases in the Largest Organ of the Human Body: (I) Basics and the Diseases of Tendon
《International Journal of Clinical Medicine》2019年第3期183-249,共67页Peter Chin Wan Fung Regina Kit Chee Kong 
We analyze the crucial biochemical and biophysical properties of the basic constituents—connective tissues (CT), and interstitial fluid (IF) constituting the non-cellular part of the fascia. We provide ample evidence...
关键词：Fascia Mechanotransduction COLLAGEN Degradation and Synthesis Durotaxis of CELLS Self-Assembly of Tropocollagen Thermal Stability of COLLAGEN Fibroblasts Stem CELLS PROTEOGLYCANS Glycoproteins Interstitial Fluid ACHILLES TENDON TENDINOPATHY 
Inhibition and enhancement of neural regeneration by chondroitin sulfate proteoglycans被引量：4
《Neural Regeneration Research》2017年第5期687-691,共5页Heikki Rauvala Mikhail Paveliev Juha Kuja-Panula Natalia Kulesskaya 
supported by the Finnish Funding Agency for Innovation Tekes,Academy of Finland;Sigrid Jusélius Foundation
The current dogma in neural regeneration research implies that chondroitin sulfate proteoglycans（CSPGs） inhibit plasticity and regeneration in the adult central nervous system（CNS）. We argue that the role of the C...
关键词：CNS injury axon regeneration dendrite regeneration PROTEOGLYCANS AGGRECAN GLYPICAN HB-GAM PLEIOTROPHIN PTEN 
Glycosaminoglycan remodeling during diabetes and the role of dietary factors in their modulation被引量：3
《World Journal of Diabetes》2016年第4期67-73,共7页Vemana Gowd Abhignan Gurukar Nandini D Chilkunda 
Glycosaminoglycans(GAGs) play a significant role in various aspects of cell physiology.These are complex polymeric molecules characterized by disaccharides comprising of uronic acid and amino sugar.Compounded to the h...
关键词：GLYCOSAMINOGLYCANS DIABETES PROTEOGLYCANS REMODELING DIETARY factors 
Proteoglycans in liver cancer被引量：11
《World Journal of Gastroenterology》2016年第1期379-393,共15页Kornélia Baghy Péter Tátrai Eszter Regős Ilona Kovalszky 
Supported by Hungarian Research Fund(OTKA)(No.100904 to Kovalszky I;and No.105763 to Baghy K)
Proteoglycans are a group of molecules that contain at least one glycosaminoglycan chain,such as a heparan,dermatan,chondroitin,or keratan sulfate,covalently attached to the protein core.These molecules arecategorized...
关键词：CANCER Cell REGULATION Heparan SULFATE LIVER PROTEOGLYCANS 
Proteoglycans: Road Signs for Neurite Outgrowth被引量：6
《Neural Regeneration Research》2014年第4期343-355,共13页Justin A.Beller Diane M.Snow 
supported by the NIH(NS53470);the Kentucky Spinal Cord and Head Injury Research Trust(#10-11A);the Department of Defense,CDMRP(SC090248/W81XWH-10-1-0778)
Proteoglycans in the central nervous system play integral roles as ＂traffic signals＂ for the direction of neurite outgrowth. This attribute of proteoglycans is a major factor in regeneration of the injured central n...
关键词：chondroitin sulfate proteoglycans heparan sulfate proteoglycans GLYCOSAMINOGLYCANS protein core extracellular matrix neuronal growth cones axon outgrowth and regeneration spinalcord injury glial scar tissue culture 
Traffic lights for axon growth: proteoglycans and their neuronal receptors被引量：1
《Neural Regeneration Research》2014年第4期356-361,共6页Yingjie Shen 
Axon growth is a central event in the development and post-injury plasticity of the nervous system. Growing axons encounter a wide variety of environmental instructions. Much like traffic lights in controlling the mig...
关键词：axonal regeneration chondroitin sulfate and heparan sulfate proteoglycans 
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