β-胡萝卜素对TAⅡ小鼠移植性乳腺癌MA_(737)影响的研究  

Effect of β carotene on mouse transplantable mammary cancer MA 737

作　　者：朱元喜[1] 郝希山[1] 孙慧[1] 王庆生[1] 

机构地区：[1]天津市肿瘤医院,天津300060

出　　处：《中华肿瘤杂志》1999年第4期262-264,共3页Chinese Journal of Oncology

摘　　要：目的　观察β胡萝卜素（ＢＣ） 对移植性乳腺癌（ＭＡ７３７） 生长、荷瘤小鼠生存期及对ＣＭＦ（ＣＴＸ、ＭＴＸ、５Ｆｕ） 化疗毒副作用的影响。方法　采用ＴＡⅡ小鼠移植性乳腺癌模型，荷瘤小鼠给予ＢＣ和（ 或）ＣＭＦ不同处理。结果　（１）ＢＣ组、ＢＣ＋ ＣＭＦ组平均每只小鼠生存时间较对照组显著延长，ＣＭＦ组小鼠因化疗毒性其生存时间较对照组明显缩短。（２） 除ＣＭＦ组小鼠在实验７ 天内全部死亡外，ＢＣ组、ＢＣ＋ ＣＭＦ组在实验不同时期肿瘤体积均明显小于对照组。（３） 长期单独灌喂ＢＣ小鼠均未出现毒副作用。（４）ＣＭＦ组小鼠在第２ 次化疗后逐渐出现严重的毒副作用，并在第３ 次化疗后全部死亡；而ＢＣ＋ ＣＭＦ组小鼠在第３ 次化疗后体重略有减轻，未出现其他不良症状，且在化疗后４ ～５ 天内体重恢复到治疗前水平。结论　ＢＣ可显著抑制ＭＡ７３７ 的生长，延长宿主的生存期，并且对ＣＭＦ化疗产生的毒副作用有明显的缓解作用，且长期灌喂安全、无毒。Objective To study the effect of β carotene (BC) on the growth of MA 737 in TAⅡ mice. Methods BC (250 mg/kg) dissolved in vegetable oil was given per os by gavage once every other day. Mice were treated with BC alone or in combination with chemotherapy (CMF protocol). Control mice were given solvent vehicle. Tumor volume and survival period of the treated and control mice were recorded.Results In mice treated with BC alone, the growth of the tumor was retarded, but the tumor inhibitory effect was more marked in mice treated with BC+CMF (growth inhibition rate: 49.1% versus 60.5%). The therapeutic effect of combined use of BC and CMF was only slightly better than that of CMF alone. However, BC helped alleviate toxic side effects of the chemotherapeutic drugs so that the survival period was significantly prolonged in the BC+CMF treated mice. Long term treatment with β carotene was without side effect.Conclusion β carotene inhibits tumor growth, prolongs survival and alleviates toxic side effects of chemotherapy in a mouse mammary cancer model.

关 键 词：乳腺癌 Β-胡萝卜素 药物疗法 

分 类 号：R737.905[医药卫生—肿瘤] R977.21[医药卫生—临床医学]