帕金森病嗅觉障碍研究进展  

Research Progress in Olfactory Dysfunction of Parkinson's Disease

作　　者：章素芳[1] 衡鑫[2,3] 乐卫东 

机构地区：[1]上海交通大学医学院附属瑞金医院神经科,上海200025 [2]中国科学院上海生命科学研究院健康科学研究所 [3]上海交通大学医学院健康科学研究所,上海200025

出　　处：《医学综述》2010年第22期3428-3431,共4页Medical Recapitulate

基　　金：上海市国际合作项目(075407066)

摘　　要：90%以上的帕金森病患者可出现嗅觉障碍,且早于运动症状数年出现,临床可表现为气味辨别、气味识别、气味记忆与再认以及气味感知等方面的缺陷。目前已建立多种检测嗅觉的方法,对帕金森病早期诊断和鉴别诊断有重要意义。帕金森病嗅觉障碍的发生机制涉及许多方面,十分复杂。现从嗅觉系统的解剖生理、嗅觉障碍的表现和检测手段、帕金森病动物模型的相关研究及嗅觉障碍的机制研究几方面进行综述。Olfactory dysfunction is found in more than 90% of Parkinson＇s disease（PD）patients and may precede the onset of motor disorders,with defects in all aspects of olfaction,including odor discrimination,identification,memory,recognition,and detection threshold.Certain methods have been established to assess the olfactory function,which plays a role in the early and differential diagnosis of Parkinson＇s disease.The mechanism of olfactory dysfunction is fairly complicated,involving many aspects.In this review,the researches on the anatomy and physiology of olfactory system,the manifestation and inspection methods of olfactory dysfunction,recent researches on mechanism and PD-related models are summarized.

关 键 词：帕金森病 嗅觉障碍 动物模型 机制 

分 类 号：R74[医药卫生—神经病学与精神病学]