supported by the National Natural Science Foundation of China(No.39070925);Shanghai International Science and Technology Coopera-tion Program(No.075407066);National High Technology Research and Development Program of China(No.2006AA02A408)
Type II DNA topoisomerases(Tops)are ATP-dependent enzymes that catalyze topological transformations of genomic DNA by the transport of one DNA double helix through another.In mammals,there are 2 isoforms of DNA Top ...