临床不安全用药行为研究及成因分析  

The Investigation of Actions and Factors Analysis of Irrational Drug Use in Clinic

作　　者：陈珲[1,2] 郭代红[3] 杜晓曦[4] 张素敏[4] 刘皈阳[3] 张素琼[4] 陈超[3] 董放[4] 史国兵[5] 张勤[6] 

机构地区：[1]解放军军医进修学院,北京100853 [2]解放军309医院药剂科,北京100091 [3]解放军总医院药品保障中心,北京100853 [4]国家食品药品监督管理局药品评价中心,北京100061 [5]沈阳军区总医院药剂科,辽宁沈阳110000 [6]成都军区总医院药剂科,四川成都610000

出　　处：《中国药物警戒》2010年第12期726-729,共4页Chinese Journal of Pharmacovigilance

基　　金：国家科技支撑课题"安全用药关键技术研究与应用"(课题编号2006BAI4B04)子课题

摘　　要：目的调查并分析住院患者的用药安全风险状况,为实施合理用药干预提供参考资料和依据。方法采用病例观察方法,监测3所综合医院于2008年5～12月,所有入住呼吸科、心内科、普外科、骨科的患者药物使用全程中的不合理现象,并进行统计学分析。结果 3家医院4 910例患者共出现不合理用药现象1 188例次、24.19%,各项观察指标中给药浓度、间隔时间、无适应证用药出现问题的频率居前3位,分别为308、214、147例次;关联因素分析结果显示人员相关者占半数;473例重点监测病例中不合理用药现象302例次,占60.85%,其中23.68%(112例次)是补充指标的贡献。结论规范临床用药的重点在于提供准确知识、加强管理监督、增强医护人员责任心。Objective To investigate and analyze the risk of safe drug use in hospital patients and in order to provide reference for administrating intervention of rational drug use.Methods To mornitor and statistical analyze the case of irrationality during whole range of drug use of all the hospital patients in Respiratory,Cardiology,General Surgery and Orthopedics in the three comprehensive hospital from May to December in 2008 with case survey of epidemiology.Results There were 1 188 cases（24.19%） of irrational drug use in 4 910 patients in the three hospitals.The frequency of problems causing by dosing concentration（308 cases）,time separation（214 cases） and Non-indication medication（147 cases） were the top three in all the index.The consequence of correlation factor showed that the half had been personal relation.There were 302 cases（60.85%） of irrational drug use in 473 enforce monitoring cases,and 23.68%（112 cases） were provided by additional index.Conclusion The key of standardize drug use in clinic,was to provide accurate knowledge,reinforce supervision and enhance responsibilities of staff in hospitals.

关 键 词：临床用药 行为 成因分析 

分 类 号：R954[医药卫生—药学]