牛磺酸对Ⅱ型糖尿病大鼠血液流变学的影响  

Effects of taurine on hemorheology of rats with type 2 diabetes

作　　者：张菲菲[1] 张艳敏[2] 门秀丽[1] 赵利军[1] 孔小燕[1] 董淑云[1] 

机构地区：[1]华北煤炭医学院病理生理教研室 [2]华北煤炭医学院附属医院,河北唐山063000

出　　处：《中国应用生理学杂志》2010年第4期474-476,共3页Chinese Journal of Applied Physiology

基　　金：唐山市科技局资助项目（08360202A-1）

摘　　要：目的：探讨牛磺酸（taurine）对Ⅱ型糖尿病（diabetes mellitus,DM）大鼠血液流变学及氧化应激的影响。方法：将40只Wistar大鼠随机取10只为正常对照组（control组）、其余30只大鼠中取20只符合模型标准的大鼠随机分为糖尿病组（DM组）和牛磺酸治疗组（Tau组,采用20g/L牛磺酸生理盐水溶液治疗,200mg/kgbw）,前两组注射等体积的生理盐水溶液。8周后,测3组大鼠血浆葡萄糖、糖化血红蛋白、超氧化物岐化酶（SOD）、丙二醛（MDA）及血液流变学指标。结果：与对照组相比,糖尿病大鼠血糖、MDA及糖化血红蛋白明显升高,SOD活性降低,全血粘度、红细胞聚集指数、红细胞压积明显增大,红细胞变形指数减小;牛磺酸能明显降低糖尿病大鼠的血糖、MDA和糖化血红蛋白（P〈0.05或P〈0.01）,显著升高造模大鼠SOD（P〈0.01）;并且明显降低大鼠全血黏度（P〈0.05）、降低红细胞聚集指数（P〈0.05）,提高红细胞变性指数（P〈0.05）。结论：牛磺酸改善糖尿病大鼠的血液流变性可能与其提高大鼠的抗氧化能力有关,对防治糖尿病血管并发症有较好作用。Objective：To observe the effects of taurine on hemorheology and oxidative stress of diabetic rats. Methods： 40 rats were divided into control group, diabetes group and treatment group at random. Diabetic model was reproduced by intraperitoneal injection of streptozotocin. After having been treated with taurine for 8 weeks, glycosylated hemoglobin （HbA1c） and the serum contents of glucose, superoxide dismutase（SOD）, malondialdehyde （MDA） were measured. The changes of hemorheology in different groups were detected respectively. Results： Compared with control group, the content of glucose, MDA and HbA1c in diabetic rats was increased, the activity of SOD was decreased, the levels of whole blood viscosity and the aggregation index of red blood cells and hematocrit were increased and RBC deformability index was decreased in diabetic rats. Moreover, taurine was able to apparently reduce high blood glucose and HbA1c（P0.05）, markedly elevated the activity of SOD, lowered the content of MDA（P0.01）; and taurine also could significantly reduce the levels of whole blood viscosity and the aggregation index of red blood cells and hematocrit in the meanwhile, and increase RBC deformability index （P0.05 or P0.01）. Conclusion： Taurine could enhance the ability of oxidation resistance, improve blood rheology property in diabetic rats, at the same time it could be beneficial to prevent and cure the development of diabetic blood vessel complication.

关 键 词：牛磺酸 大鼠 糖尿病 血液流变学 

分 类 号：R282.5[医药卫生—中药学]