妊娠期糖尿病分子遗传学研究进展  

Advancement in research on molecular genetics of gestational diabetes mellitus

作　　者：周琦[1,2] 聂敏[1] 孙梅励[1] 郑景晨[2] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院内分泌科卫生部内分泌重点实验室,北京100730 [2]温州医学院附属第一医院内分泌科,浙江温州325000

出　　处：《生殖医学杂志》2010年第6期530-534,共5页Journal of Reproductive Medicine

基　　金：国家自然科学基金项目(30672210及81070630)

摘　　要：妊娠期糖尿病(GDM)是指妇女在妊娠期发生或首次发现的不同程度的糖耐量异常。与妊娠相关的胰岛素抵抗程度超过了胰岛β细胞功能代偿的极限是目前较为公认的GDM发病原因,但其具体的发病机制尚不完全清楚。近年的研究表明,遗传因素在GDM的发生发展中起重要作用,一些基因的多态性可能影响到个体GDM易感性的差异。现就近年的关GDM基因多态性方面的研究做一综述。Gestational diabetes mellitus （GDM） is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. It is manifested when the function of pancreatic beta cells is unable to compensate for the increased insulin resistance during pregnancy. The patbogenesis of the disease, however, is still unknown. Recently, many studies have shown that genetic factors may play an important role in the development of GDM, and some genetic polymorphisms are related to this disease. This review mainly focuses on the advancement in genetic polymorphisrns of GDM.

关 键 词：妊娠期糖尿病 多态性 

分 类 号：R[医药卫生]