Effects of pallidal neurotensin on haloperidol-induced parkinsonian catalepsy: behavioral and electrophysiological studies  

苍白球神经降压素对氟哌啶醇所致帕金森病僵直症状的影响:行为学和电生理学研究(英文)

作　　者：薛雁[1] 陈蕾[1] 

机构地区：[1]青岛大学医学院生理学教研室,青岛266071

出　　处：《Neuroscience Bulletin》2010年第5期345-354,共10页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.30870800);the Ph.D Program Foundation of Ministry of Education,China(No.200810650002);the Bureau of Science and Technology of Qingdao Municipal,China(No.08-2-1-2-nsh)

摘　　要：Objective The globus pallidus plays a critical role in movement regulation. Previous studies have indicated that the globus pallidus receives neurotensinergic innervation from the striatum, and systemic administration of a neurotensin analog could produce antiparkinsonian effects. The present study aimed to investigate the effects of pallidal neurotensin on haloperidol-induced parkinsonian symptoms. Methods Behavioral experiments and electrophysiological recordings were performed in the present study. Results Bilateral infusions of neurotensin into the globus pallidus reversed haloperidolinduced parkinsonian catalepsy in rats. Electrophysiological recordings showed that microinjection of neurotensin induced excitation of pallidal neurons in the presence of systemic haloperidol administration. The neurotensin type-1 receptor antagonist SR48692 blocked both the behavioral and the electrophysiological effects induced by neurotensin. Conclusion Activation of pallidal neurotensin receptors may be involved in neurotensin-induced antiparkinsonian effects.目的苍白球在机体运动功能调节中发挥重要作用。形态学研究证实苍白球接受来自纹状体的神经降压素能纤维支配。有研究报道全身给予神经降压素类似物可诱导产生抗帕金森病效应。本研究旨在探讨苍白球神经降压素对氟哌啶醇所致的帕金森病僵直症状的影响。方法用行为学实验检测大鼠的帕金森病僵直症状,用电生理学实验方法记录苍白球神经元的自发放频率。结果双侧苍白球微量注射神经降压素可以缓解氟哌啶醇所致的帕金森病僵直症状。在氟哌啶醇条件下,微量注射神经降压素可以兴奋苍白球神经元。选择性神经降压素1型受体拮抗剂SR48692可以拮抗神经降压素所致的行为学和电生理学效应。结论上述结果提示,神经降压素的抗帕金森病作用可能与苍白球神经降压素受体的激活有关。

关 键 词：globus pallidus NEUROTENSIN Parkinson’s disease single unit recordings 

分 类 号：R742.5[医药卫生—神经病学与精神病学]