NEUROTENSIN

作品数：27被引量：63H指数：4
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相关领域：医药卫生更多>>
相关作者：张坤陈京蔡欣白波陈蕾更多>>
相关机构：北京协和医学院济宁医学院安徽医科大学第三军医大学西南医院更多>>
相关期刊：《Bioactive Materials》《Neuroscience Bulletin》《Acta Pharmacologica Sinica》《Science China Chemistry》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划山东省自然科学基金更多>>
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Neurotensin signaling in fat modulates food intake
《Cell Research》2025年第2期85-86,共2页YoungUk Jang Prashant Rajbhandari 
White adipose tissue is a highly specialized organ that not only stores excess calories but also helps control systemic energy and glucose metabolism as an active endocrine organ.Fu et al.’s new study in Cell Researc...
关键词：INTAKE METABOLISM al. 
Decreased neurotensin induces ovulatory dysfunction via the NTSR1/ERK/EGR1 axis in polycystic ovary syndrome
《Frontiers of Medicine》2025年第1期149-169,共21页Dongshuang Wang Meiling Zhang Wang-Sheng Wang Weiwei Chu Junyu Zhai Yun Sun Zi-Jiang Chen Yanzhi Du 
supported by grants from the National Key Research and Development Program of China(Nos.2022YFC2703204 and 2021YFC2701104);the National Natural Science Foundation of China(Nos.81971343 and 82171623);the National Institutes of Health Project(No.1R01HD085527),the Innovative research team of high-level local universities in Shanghai(No.SHSMU-ZLCX20210200);Shanghai Commission of Science and Technology(Nos.21XD1401900 and 20DZ2270900);Three-Year Action Plan for Strengthening the Construction of the Public Health System in Shanghai(No.GWVI-11.1-36);Shanghai’s Top Priority Research Center Construction Project(No.2023ZZ02002).
Polycystic ovary syndrome(PCOS)is the predominant cause of subfertility in reproductive-aged women;however,its pathophysiology remains unknown.Neurotensin(NTS)is a member of the gut–brain peptide family and is involv...
关键词：NEUROTENSIN neurotensin receptor 1 early growth response l polycystic ovary syndrome ovulatory disfunction 
Neurotensin-neurotensin receptor 2 signaling in adipocytes suppresses food intake through regulating ceramide metabolism
《Cell Research》2025年第2期117-131,共15页Wei Fu Yuanting Lai Kexin Li Yue Yang Xiao Guo Qifan Gong Xiaofeng Zhou Liying Zhou Cenxi Liu Zhi Zhang Jisun So Yufeng Zhang Lin Huang Guangxing Lu Chuanyou Yi Qichu Wang Chenyu Fan Chao Liu Jiaxing Wang Haiyi Yu Yimin Zhao Tao Huang Hyun Cheol Roh Tiemin Liu Huiru Tang Jianping Qi Ming Xu Yan Zheng He Huang Jin Li 
supported by the National Key R&D Program of China from Ministry of Science&Technology(2020YFA0803800,2019YFA0801900,NSFC92057115);Shanghai Sailing Program 20YF1402600 to H.H.,the National Key R&D Program of China from Ministry of Science&Technology(2020YFA0803600,2018YFA0801300,2023YFA1801000 to J.L.);the National Natural Science Foundation of China(32071138 and 32371193 to J.L.),and SKLGE-2118 to J.L.
Neurotensin(NTS)is a secretory peptide produced by lymphatic endothelial cells.Our previous study revealed that NTS suppressed the activity of brown adipose tissue via interactions with NTSR2.In the current study,we f...
关键词：INTAKE METABOLISM Together 
Neurotensin Modulates Emotional Valence Assignment in the Basolateral Amygdala Through Neuromodulator Gain
《Neuroscience Bulletin》2025年第1期177-180,共4页Maimaitishalijiang Abudureheman Yu-Hao Xiao Li-Zang Zeng Hong-Yan Geng 
supported by grants from the Key-Area Research and Development Program of Guangdong province(2019B030335001);the National Natural Science Foundation of China(32200815);the China Postdoctoral Science Foundation(2022M721218).
Based on previous experience,learning to avoid or seek certain specific stimuli again in the future is crucial for survival.Our brains are wired to assign a particular valence-either positive or negativeas a result of...
关键词：EMOTIONAL MOTIVATION MODULATOR 
Control of Emotion and Wakefulness by Neurotensinergic Neurons in the Parabrachial Nucleus被引量：1
《Neuroscience Bulletin》2023年第4期589-601,共13页Jingwen Chen Noam Gannot Xingyu Li Rongrong Zhu Chao Zhang Peng Li 
supported by the University of Michigan startup funds and the NIH Grants R01 AT011652 and R01 HL156989.
The parabrachial nucleus(PBN)integrates interoceptive and exteroceptive information to control various behavioral and physiological processes including breathing,emotion,and sleep/wake regulation through the neural ci...
关键词：Parabrachial nucleus NEUROTENSIN ANXIETY Sleep WAKEFULNESS BREATHING Neural circuit FREEZING MEDULLA 
Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration被引量：1
《Neural Regeneration Research》2022年第4期854-866,共13页Manuel A.Fernandez-Parrilla David Reyes-Corona Yazmin M.Flores-Martinez Rasajna Nadella Michael J.Bannon Lourdes Escobedo Minerva Maldonado-Berny Jaime Santoyo-Salazar Luis O.Soto-Rojas Claudia Luna-Herrera Jose Ayala-Davila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez Irma A.Martínez-Dávila Porfirio Nava Daniel Martinez-Fong 
supported by the Consejo Nacional de Ciencia Tecnología(Conacyt)de México(Grant#254686,to DMF)。
Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's disease.The human cerebral dopamine...
关键词：axonal growth brain-derived neurotrophic factor gene delivery NANOPARTICLES NEURITOGENESIS neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's disease REINNERVATION substantia nigra 
Novel opioid-neurotensin-based hybrid peptide with spinal long-lasting antinociceptive activity and a propensity to delay tolerance development
《Acta Pharmaceutica Sinica B》2020年第8期1440-1452,共13页Karolina Fra˛czek Mattia Ferraiolo Emmanuel Hermans Magdalena Bujalska-Zadrozny Kaja Kasarello Anna Erdei Kamila Kulik Agnieszka Kowalczyk Piotr Wojciechowski Dorota Sulejczak Piotr Sosnowski Sebastian Granica Sandor Benyhe Katarzyna Kaczynska Lukasz Nagraba Artur Stolarczyk Agnieszka Cudnoch-Jedrzejewska Patrycja Kleczkowska 
financed by the EU—the European Regional Development Fund within the Operational Program“Innovative economy”for 2007-2013
The behavioral responses exerted by spinal administration of the opioid-neurotensin hybrid peptide, PK23, were studied in adult male rats. The antinociceptive effect upon exposure to a thermal stimulus, as well as tol...
关键词：OPIOID NEUROTENSIN doses 
Controlled-release neurotensin-loaded silk fibroin dressings improve wound healing in diabetic rat model被引量：7
《Bioactive Materials》2019年第1期151-159,共9页Jianghui Liu Liwei Yan Wei Yang Yong Lan Qiyu Zhu ongjie Xu Canbin Zheng Rui Guo 
supported financially by the Natural Science Foundation of China(51303064 and 31271019);the Science and Technology Program of Guangzhou(201601010270,2017010160489,201704030083);the Pearl River S&T Nova Program of Guangzhou(201710010155,201806010072);the Science and Technology Project of Guangdong province(2015A010101313,2017A050506011,2017B090911012,2018A050506040,2018A050506019,2018A050506021).
Diabetic foot ulcers(DFU),which may lead to lower extremity amputation,is one of the severe and chronic complications of diabetic mellitus.This study aims to develop,and use dressings based on Silk fibroin(SF)as the s...
关键词：Diabetic foot ulcers(DFU) Silk fibroin(SF) Gelatin microspheres(GMs) Neurotensin(NT) Rat diabetic model 
Optical coherence tomography and T cell gene expression analysis in patients with benign multiple sclerosis
《Neural Regeneration Research》2017年第8期1352-1356,共5页John Soltys Qin Wang Yang Mao-Draayer 
funded by an investigator-initiated,unrestricted research grant(to YMD)from Biogen Idec.YMD served as a consultant and/or received grant support from:Acorda,Bayer Pharmaceutical,EMD Serono,Genzyme,Novartis,Questor,Teva Neuroscience and Chugai Pharma;supported by grants from NIH NIAID Autoimmune Center of Excellence:UM1-AI110557;NIH NINDS R01-NS080821,Novartis and Chugai(to YMD)
Benign multiple sclerosis is a retrospective diagnosis based primarily on a lack of motor symptom progression. Recent findings that suggest patients with benign multiple sclerosis experience non-motor symptoms highlig...
关键词：neurotensin high affinity receptor 1 benign multiple sclerosis optical coherence tomography interleukin 10 T cell leukemia inhibitory factor optic neuritis neural regeneration 
Interferon beta(IFN-β) treatment exerts potential neuroprotective effects through neurotrophic factors and novel neurotensin/neurotensin high affinity receptor 1 pathway被引量：2
《Neural Regeneration Research》2015年第12期1932-1933,共2页Qin Wang Yang Mao-Draayer 
Dr.Mao-Draayer has served as a consultant and/or received grant support from:Acorda,Bayer Pharmaceutical,Biogen Idec,EMD Serono,Genzyme,Novartis,Questor,Teva Neuroscience and Chugai Pharma;Dr.Mao-Draayeris currently supported by grants from NIH NIAID Autoimmune Center of Excellence:UM1-AI110557;NIH NINDS R01-NS080821;the University of Michigan Neurology Department
Multiple sclerosis（MS）is a chronic autoimmune disease of the central nervous system（CNS）characterized by coexisting processes of inflammation,demyelination,axonal neurodegeneration,and gliosis.It is the most commo...
关键词：IFN treatment exerts potential neuroprotective effects through neurotrophic factors and novel neurotensin/neurotensin high affinity receptor 1 pathway Interferon beta high 
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