Control of Emotion and Wakefulness by Neurotensinergic Neurons in the Parabrachial Nucleus  

作　　者：Jingwen Chen Noam Gannot Xingyu Li Rongrong Zhu Chao Zhang Peng Li 

机构地区：[1]Fundamental Research Center,Shanghai Yangzhi Rehabilitation Hospital,School of Life Sciences and Technology,Tongji University,Shanghai,201619,China [2]Life Sciences Institute,University of Michigan,Ann Arbor,MI,48109,USA [3]Department of Biologic and Materials Sciences,School of Dentistry,University of Michigan,Ann Arbor,MI 48109,USA [4]Department of Molecular and Integrative Physiology,School of Medicine,University of Michigan,Ann Arbor,MI 48109,USA

出　　处：《Neuroscience Bulletin》2023年第4期589-601,共13页神经科学通报（英文版）

基　　金：supported by the University of Michigan startup funds and the NIH Grants R01 AT011652 and R01 HL156989.

摘　　要：The parabrachial nucleus(PBN)integrates interoceptive and exteroceptive information to control various behavioral and physiological processes including breathing,emotion,and sleep/wake regulation through the neural circuits that connect to the forebrain and the brainstem.However,the precise identity and function of distinct PBN subpopulations are still largely unknown.Here,we leveraged molecular characterization,retrograde tracing,optogenetics,chemogenetics,and electrocortical recording approaches to identify a small subpopulation of neurotensin-expressing neurons in the PBN that largely project to the emotional control regions in the forebrain,rather than the medulla.Their activation induces freezing and anxiety-like behaviors,which in turn result in tachypnea.In addition,optogenetic and chemogenetic manipulations of these neurons revealed their function in promoting wakefulness and maintaining sleep architecture.We propose that these neurons comprise a PBN subpopulation with specific gene expression,connectivity,and function,which play essential roles in behavioral and physiological regulation.

关 键 词：Parabrachial nucleus NEUROTENSIN ANXIETY Sleep WAKEFULNESS BREATHING Neural circuit FREEZING MEDULLA 

分 类 号：R741[医药卫生—神经病学与精神病学]