牛磺酸防治酒精性脂肪肝作用机制的探讨  

STUDY ON THE THERAPEUTIC EFFECT OF TAURINE ON THE ALCOHOLIC FATTY LIVER

作　　者：宋春霞[1] 张国顺[2] 张超[2] 王玉兰[2] 徐晓平[2] 

机构地区：[1]唐山市传染病院,唐山063000 [2]华北煤炭医学院附属医院消化内科

出　　处：《现代预防医学》2011年第1期21-22,共2页Modern Preventive Medicine

基　　金：唐山市科技攻关指令项目(081302010)

摘　　要：[目的]研究牛磺酸防治酒精性脂肪肝的作用机制。[方法]将小鼠随机分为5组,包括正常对照组、酒精性脂肪肝模型组、牛磺酸高中低3个剂量组。30d后分别检测肝脏中脂褐质LF、血清MDA、SOD以及GSH-Px等指标。[结果]牛磺酸能显著降低小鼠血清MDA和肝脏中脂褐质LF的含量,并增强血清中SOD以及GSH-PX的活性。[结论]牛磺酸可能通过抗氧化的途径来减轻酒精性脂肪对小鼠的损伤。[Objective] To study the therapeutic effect of taurine on the alcoholic fatty liver. [ Methods] Mice were randomized into 5 groups, including normal control group, model group of alcoholic fatty liver and 3 intervendonal taurine groups. 30 days later, the contents of LF in the liver, MDA, SOD and GSH-PX activities were measured. [Results] Taurine reduced the levels of MDA and LF significantly and also increased the activities of SOD and GSH-PX. [Conclusion] Taurine may improve the alcoholic fatty liver by its and-oxidative action.

关 键 词：牛磺酸 酒精性脂肪肝 抗氧化 

分 类 号：R575.5[医药卫生—消化系统]