小儿急性淋巴细胞白血病IgH及TCR γ基因重排研究  

Rearrangements of Immunoglobulia Heavy Chain and TLymphocytic Receptor Genes in Acute Lymphoblastic Leukemia of Childhood

作　　者：周红平[1] 饶兆英[1] 曾毓华[1] 李招金[1] 

机构地区：[1]江西省儿童医院

出　　处：《实用癌症杂志》1999年第2期111-113,共3页The Practical Journal of Cancer

摘　　要：应用ＰＣＲ对３３例小儿急性淋巴细胞白血病（ＡＬＬ）进行免疫球蛋白重链（ＩｇＨ）及Ｔ细胞受体γ（ＴＣＲγ）基因重排研究，以探讨该２种重排在小儿ＡＬＬ的发生规律及与免疫分型的关系。结果显示：ＩｇＨ阳性１９例（５７．６％），ＴＣＲγ阳性１０例（３０．３％）。有７例ＩｇＨ及ＴＣＲγ均呈阳性，其中５例来自Ｂ系或Ｔ系分化早期的淋巴细胞白血病，提示在儿童初发淋巴细胞白血病中，ＩｇＨ基因重排的发生率明显高于ＴＣＲγ基因重排，且在免疫表型为分化早期的Ｔ或Ｂ淋巴细胞白血病中，并存上述２种基因重排的可能性很大。In order to investigate the pathogenic regularity and the relationship of immunophenotype with two gene rearrangements of immunoglobulin heavy chain(IgH) and Tlymphocytic receptor (TCR) in childhood acute lymphoblastic leukemia(ALL),33 cases were studied with polymerase chain reaction(PCR) method.The results showed that,of the 33 cases,19(57.6%) were IgH positive and 10(30.3%) were TCR positive.7 cases were positive in both IgH and TCR and 5 of the 7 cases came from precursorB and Tlymphoblastic leukemia.It indicated that the positive rate in gene rearrangment of IgH would be higher than that of TCR in ALL of childhood and the possibility of both IgH and TCR gene rearrangement could be high in those cases of precursorB or T immunophenotype

关 键 词：T细胞受体Γ 白血病 ALL 基因重排 IGH 

分 类 号：R733.71[医药卫生—肿瘤]