黑老虎果毒理实验及其对血脂的调节作用  

An Experimental Animal Investigation on Toxicity and Blood Lipid Modulating Effect of Kadsura coccinea Fruit

作　　者：李志春[1,2] 孙健[1,2] 封毅[3] 卓少元[3] 乐宁[3] 尧金燕[4] 龙兴[4] 

机构地区：[1]广西农业科学院农产品加工研究所,广西南宁530007 [2]广西作物遗传改良重点开放实验室,广西南宁530007 [3]广西中医学院基础医学院,广西南宁530001 [4]广西农业科学院园艺研究所,广西南宁530007

出　　处：《食品科学》2011年第1期203-205,共3页Food Science

基　　金：广西自然科学基金项目(2010GXNSFB013034;2010GXNSFC013010);广西农业科学院博士启动基金项目(20090306)

摘　　要：研究成熟黑老虎果的毒性及其对血脂的调节作用。对实验小鼠进行急性毒理实验,同时进行30d喂养实验,并观察小鼠血脂的变化。结果表明:雌雄小鼠经口最大耐受剂量(MTD)>20mL/kg(以体质量计),属无毒级;30d喂养实验各项观察指标正常,黑老虎果对小鼠的体质量、血液、脏器等均无显著影响;该果能明显降低小鼠血液中胆固醇水平。可以认为,成熟黑老虎果是值得开发的无毒且可调节血脂的珍稀野生水果。The aim of this study was to investigate the toxicity and blood lipid modulating effect of ripe Kadsura conccinea fruit in vivo by maximal tolerance dose（MTD） test and 30-d feeding test in mice.Blood lipid changes in mice were analyzed during 30 days of Kadsura conccinea fruit feeding.The results showed MTD was 20 mL/kg for both male and female mice,indicating that Kadsura conccinea fruit was non-toxic.Kadsura conccinea fruit had significant effect on neither mouse weight nor viscera but could obviously reduce the level of cholesterol in mouse blood.Thus,it can be considered that ripe Kadsura conccinea fruit deserves to be exploited as a rare wild fruit with the benefits of non-toxicity and modulating blood lipids.

关 键 词：黑老虎果 毒性 血脂 调节 

分 类 号：R994.4[医药卫生—毒理学]