N-芳烷基取代苯乙醇胺类化合物的合成及药理活性  

The Synthesis of N aralkyl Substituted Phenoethanol Amines and Studies on Their Pharmacological Activities

作　　者：黄惠琴[1] 赵冬梅[2] 赵丽琴[2] 张雅芳[2] 沈建民[2] 王玉萍[3] 

机构地区：[1]中国医学科学院药物研究所,北京100050 [2]沈阳药科大学合成二室,沈阳110015 [3]中国医科大学药理教研室,沈阳110003

出　　处：《中国药物化学杂志》1999年第3期196-199,共4页Chinese Journal of Medicinal Chemistry

摘　　要：以β２肾上腺素受体激动剂福莫特罗为原型化合物，合成了９ 个Ｎ芳烷基取代苯乙醇胺类化合物，除化合物ＨＱ０３ 外，其余８ 个化合物均未见文献报道．初步药理实验结果表明：部分化合物具有较强的生物活性．Nine N aralkyl substituted phenoethanol amines were designed and synthesized in this paper.All of them have not been reported in literature except for HQ 03.Pharmacological tests showed that eight target compounds had action on the contracting smooth muscles of guinea pigs,and HQ 01,03,04 were the most potent compounds.

关 键 词：哮喘 肾上腺素受体 激动剂 福莫特罗 

分 类 号：TQ463.54[化学工程—制药化工] R974.3[医药卫生—药品]