多耐药基因P-gp、GST-π与CerbB-2、LN-R在膀胱癌中的表达及临床研究  

Multidrug resistance gene P-gp, GST-π and CerbB-2, LN-R in bladder Carcinoma and clinical study

作　　者：何斌[1] 焦丹[1] 张徐龙[1] 

机构地区：[1]酒泉市人民医院泌尿外科,甘肃735000

出　　处：《国际泌尿系统杂志》2011年第1期19-23,共5页International Journal of Urology and Nephrology

摘　　要：目的 探讨膀胱癌组织中P-糖蛋白（P-gp）和谷胱甘肽S转移酶（GST-π）与CerbB-2、层黏连蛋白受体（LN-R）的表达及其临床意义.方法 回顾性分析膀胱癌的临床与病历资料,应用免疫组织化学方法检测45例膀胱异性细胞癌中P-gp、GST-π和CerbB-2、LN-R基因的表达情况.结果 P-gp、GST-π、CerbB-2和LN-R在膀胱癌中的阳性率分别为42.22%、48.88%、46.66%和37.78%.P-gp、GST-π与CerbB-2在膀胱癌中的表达分级、分期比较差异有统计学意义（p＜0.05）;LN-R在转移/未转移病例的表达中比较差异有统计学意义（p＜0.05）;P-gp、GST-π与LN-R在2年内复发肿瘤的阳性率高于2年后复发肿瘤,相互间差异具有统计学意义（p＜0.05）.结论 P-gp、GST-π、CerbB-2表达与膀胱癌的分期、分级、复发等呈正相关（p＜0.05）,随肿瘤分级、分期、浸润性增高,其阳性表达率亦增高,同时P-gp、GST-π可指导膀胱癌化疗药物的选择;LN-R的表达与膀胱癌的转移呈正相关（p＜0.05）,可作为判断膀胱癌预后的因素.Objectives To investigate bladder cancer P - glycoprotein （ P - gp） and g, lutathione S transferass （GST-π） and CerbB-2, laminin receptor （LN -R） expression and clinical significance. Methods Retrospective analysis of bladder cancer and medical records, were detected by immunohistochemistry in 45 cases of bladder cell carcinoma of the opposite sex in the P - gp, GST - π and CerbB -2, LN - R gene expression. Results P - gp, GST - r, CerbB -2 and LN - R in bladder cancer, the positive rate was 42.22%, 48.88%, 46.66%and 37.78%. P -gp, GST- r and CerbB -2 expression in bladder cancer grade, stage the difference was statistically significant（ p〈0.05）;LN-Rin the transfer / no transfer of cases to compare differences in the expression of statistically significant （p〈0.05）;P-gp,GST-π and LN - R tumor recurrence within 2 years, the positive rate of tumor recurrence after 2 years, statistically significant differences between each other （ p〈0.05）. Conclusions P-gp, GST-π, CerbB - 2 expression and bladder cancer stage, grade, recurrence was a positive corelation（ p〈0.05）, with the tumor grade, stage, invasive increased, the positive expression rate also increased,while P - gp, GST - π can guide the choice of chemotherapy of bladder cancer; LN - R expression and metastasis of bladder cancer was positively correlated（ p〈0.05）, could be used as prognostic factors in bladder cancer.

关 键 词：膀胱肿瘤 基因 MDR 

分 类 号：R737.14[医药卫生—肿瘤]