SUFU在胰腺癌组织中的表达及其临床意义  

Expression and significance of SUFU in pancreatic carcinoma

作　　者：王云锋[1] 满晓华[1] 高军[1] 杜奕奇[1] 龚燕芳[1] 李兆申[1] 金晶[1] 吴红玉[1] 

机构地区：[1]第二军医大学长海医院消化内科,上海200433

出　　处：《中华胰腺病杂志》2010年第6期418-420,共3页Chinese Journal of Pancreatology

基　　金：国家科技支撑计划（2006BAI02A12）

摘　　要：目的 探讨SUFU蛋白在胰腺癌组织中的表达及其与临床病理特征之间的关系.方法 应用免疫组化法检测SUFU蛋白在28例胰腺癌手术切除标本、20例癌旁咦腺组织及4例正常胰腺组织中的表达,分析其与胰腺癌临床病理特征间的关系.结果 SUFU蛋白阳性表达于胰腺导管癌细胞的胞质和胞核,阳性表达率为78.6%（22/28）,其中＋6例,＋＋13例,＋＋＋3例.癌旁胰腺组织及正常胰腺组织中导管、腺泡和胰岛均未见SUFU蛋白表达,与咦腺癌组织比较,相差显著（P＜0.05）.胰腺癌组织SUFU蛋白高表达与患者的年龄、性别、肿瘤部位、肿瘤大小、淋巴转移和肝转移无关,而与肿瘤的临床分期之间呈正相关（P＜0.05）.结论 SUFU蛋白在胰腺癌组织中高表达,对胰腺癌发病具有一定作用.Objective To investigate the expression of SUFU protein in human pancreatic carcinoma tissues and to explore the relationship between the expression of SUFU protein and the clinicopathologic parameters.Methods The expression of SUFU protein in 28 samples of pancreatic cancer tissues and 20 adjacent normal pancreatic tissues and 4 normal pancreatic tissues was detected by immunohistochemical method.And the relationship between the expression of SUFU protein and the clinicopathologic parameters were determined.Results SUFU protein was positively expressed in cytoplasm and nucleus of pancreatic carcinoma cells, while it was not expressed in the duct, acinar and islet of tumor-adjacent tissues and normal pancreatic tissues, and difference was statistically significant （P 〈 0.05）.The high SUFU protein expression was related to the clinical stage （ P 〈 0.05 ）, but not the age, gender, tumor location , tumor size, lymph node metastasis and liver metastasis.Conclusions SUFU protein was highly expressed in pancreatic cancer, and SUFU may play certain role in the pathogenesis of pancreatic cancer.

关 键 词：胰腺肿瘤 免疫组织化学 HEDGEHOG通路 SUFU 

分 类 号：R735.9[医药卫生—肿瘤]