n-3脂肪酸代谢产物抗炎作用的研究进展  

Progress in Anti-inflammation Effect of n-3 Fatty Acid Metabolites

作　　者：张俊杰[1] 周克元[2] 蔡春[1] 

机构地区：[1]广东医学院分析中心,湛江524023 [2]广东医学院生物化学与分子生物学研究所,湛江524023

出　　处：《生物化学与生物物理进展》2011年第1期20-27,共8页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金资助项目(30672741)~~

摘　　要：炎症反应是机体正常组织对感染和损伤的应答,然而过度的炎症反应往往会引起急性和慢性疾病的发生.最近研究发现,由n-3多不饱和脂肪酸二十碳五烯酸和二十二碳六烯酸代谢产生的resolvins和protectins两类化合物,具有很强的抗炎和炎症修复活性.综述了resolvins和protectin D1的来源、抗炎作用和抗炎机制,为进一步开展n-3多不饱和脂肪酸及其代谢产物的抗炎作用研究、为炎症的防治提供新的思路.Inflammation is the normal host tissue response to infection and injury.However uncontrolled and unresolved inflammation contributes to a range of acute and chronic human disease.Recent results have demonstrated several new families of lipid mediators,derived from eicosapentaenoic acid（EPA） and docosahexaenoic acid（DHA） of n-3 serial fatty acid,that including resolvins and protectins,to be both anti-inflammation and proresolving.Biosynthesis,anti-inflammatory action and mechanism of these new proresolving lipid mediators were described in order to complete the anti-inflammatory mechanism of n-3 polyunsaturated fatty acid and offer exciting new potential for therapeutic control.

关 键 词：RESOLVINS protectinD1 N-3脂肪酸 炎症 

分 类 号：Q547[生物学—生物化学]