灵芝复康宝对荷瘤鼠IL-2及TNF-α的诱生作用  

The induction of IL 2 and TNF αin tumor bearing miceby Lingzhifukangbao

作　　者：郑振[1] 沈自尹[1] 俞红[2] 姚明[3] 黄辉[2] 

机构地区：[1]上海医科大学中西医结合研究所,上海200040 [2]上海医科大学免疫学教研室,上海200032 [3]上海肿瘤研究所,上海200032

出　　处：《癌症》1999年第4期379-381,共3页Chinese Journal of Cancer

摘　　要：目的： 探讨灵芝复康宝抗肿瘤作用的免疫学机理。方法： 采用 Ｅ Ｌ Ｉ Ｓ Ａ 法则定不同剂量芝复康宝对 Ｓ１８０ 荷瘤小鼠血清 Ｉ Ｌ２ 、 Ｔ Ｎ Ｆα含量的影响。结果：小剂量组（０ ．５ ｍｇ／ｋｇ 体重） 血清 Ｉ Ｌ２ 和 Ｔ Ｎ Ｆα水平明显高于对照组（ Ｐ＜ ０．０５） 。结论：小剂量的灵芝复康宝对荷瘤鼠 Ｉ Ｌ２ 和 Ｔ Ｎ Ｆα均有一定的诱生作用，提示小剂量的灵芝复康宝可能通过调节宿主 Ｂ Ｒ Ｍ（ｂｉｏｌｏｇｉｃａｌｒｅｓｐｏｎｓｅ ｍｏｄｉｆｉｅｒｓ ， Ｂ Ｒ Ｍ） 系统而发挥其抑制肿瘤的作用。Objective:To investigate the immunological mechanisms responsible for the anti tumor effects of Lingzhifukangbao (LZFKB).Methods:ELISA was performed for the quantitative measurement of IL 2 and TNF α in S180 bearing mice serum.Results:The levels of IL 2 and TNF α in serum were significantly higher in the small dose group (0.5 mg/kg) as compared with the the control. Conclusions:A small dose LZFKB could induce IL 2 and TNF αin tumor bearing mice, which suggests that a small dose LZFKB may suppress tumor growth by regulating host's biological response modifiers(BRM)system.

关 键 词：灵芝复康宝 免疫药理学 IL-2 TNFΑ 肿瘤 

分 类 号：R730.53[医药卫生—肿瘤] R967[医药卫生—临床医学]