花色苷对高脂血症人群血脂及体内氧化应激水平的影响  

EFFECT OF ANTHOCYANINS ON OXIDATIVE STRESS IN SUBJECTS WITH HYPERLIPIDEMIA

作　　者：牟海英[1] 屈琪[1] 刘静[1] 秦玉[1] 凌文华[1] 马静[1] 

机构地区：[1]中山大学公共卫生学院营养学系,广州510080

出　　处：《营养学报》2010年第6期551-555,共5页Acta Nutrimenta Sinica

基　　金：国家自然科学基金(No.30730079)

摘　　要：目的比较纯品花色苷、黑米花色苷对高脂血症人群体内氧化应激水平的影响。方法选取高脂血症志愿者90名,按性别、年龄、收入、教育、患病服药情况匹配后随机分为黑米花色苷、纯品花色苷、安慰剂三组,每组30例,分别给予对应胶囊,每日2次,每次2粒(黑米花色苷提取物200 mg/d,纯品花色苷320 mg/d,淀粉糊精1000 mg/d),连续12w,于干预前后进行体格测量、膳食调查,并留血、尿样本检测氧化应激指标。结果干预前后各组每日膳食摄入量、营养素摄入量及供能百分比差异无统计学意义(P>0.05);黑米花色苷组干预后血清TC、TG较干预前明显降低(P<0.05);纯品花色苷组干预后血清TC、LDL较干预前明显降低(P<0.05),HDL与干预前比较明显升高(P<0.05);安慰剂组血脂各项指标干预前后无明显变化(P>0.05)。干预后纯品花色苷组的T-AOC水平较干预前以及与安慰剂组比较明显升高(P<0.05);黑米花色苷组干预后及与安慰剂组比较,差异无统计学意义(P>0.05)。干预后纯品花色苷及黑米花色组血清总SOD活性比干预前明显升高(P<0.05);亦明显高于安慰剂组(P<0.05)。三组间干预前后尿8-异前列烷浓度差异无统计学意义(P>0.05)。结论黑米花色苷与纯品花色苷具有不同程度改善高脂血症人群血脂及体内氧化应激水平的作用。Objective Whether sterling anthocyanin and anthocyanin-rich extract of black rice（AREBR） may increase the level of antioxidation in subjects with hyperlipidemia.Methods Ninety volunteers with hyperlipidemia that were matched to sex,age,income,education,medicine using were divided equally into three groups.They were given AREBR or sterling anthocyanin or placebo for 12w.Results There was no difference in the there groups in daily food or nutrients intakes before and after intervention（P〉0.05）,Serum TC and LDL-cholesterol concentrations were significantly decreaced after intervention（P〈0.05） while serum HDL-cholesterol concentrations were significantly up-regulated（P〈0.05） in sterling anthocyanin group.In AREBR group,serum TC and TG concentrations were significantly descended after intervention（P〈0.05）.In sterling anthocyanin group,the concentrition of plasma T-AOC was significantly increased after intervention and was significantly higher than the placebo group（P〈0.05）.Plasma SOD was significantly increaced after intervention both in sterling anthocyanin group and AREBR group（P〈0.05）,and was significantly higher than the placebo group（P〈0.05）.There was no difference in each index of placebo group after intervention for 12 w（P〉0.05）.There were no significant differences in urine 8-isoprostanes among 3 groups before or after intervention（P〉0.05）.Conclusion Sterling anthocyanin or AREBR supplementation can improve lipid profile and oxidative stress in hyperlipidemic patients.

关 键 词：花色苷 总抗氧化能力 超氧化物歧化酶 8-异前列烷 高脂血症 

分 类 号：R151.2[医药卫生—营养与食品卫生学]