溴化正丁基吡啶增敏2'-羟基查耳酮的碱催化环化反应研究  

Study on the cyclization reaction and kinetic character of 2'-hydroxychalcone under alkaline with n-butylpyridinium bromide as sensitizer

作　　者：谢晶晶[1] 郑旭煦[1] 殷钟意[1] 何文香[1] 张玉静[1] 

机构地区：[1]重庆工商大学环境与生物工程学院药物化学与化学生物学研究中心,重庆400067

出　　处：《化学研究与应用》2011年第2期199-203,共5页Chemical Research and Application

基　　金：教育部科学技术研究重点项目(208119)资助;重庆工商大学研究生创新科研项目(yjscxx2009-07)资助

摘　　要：考察了溴化N-烷基吡啶存在下的2'-羟基查耳酮碱催化环化反应及动力性质。结果表明,溴化正丁基吡啶能有效促进NaOH催化2'-羟基查耳酮转化为黄烷酮,在室温下反应2 h,黄烷酮产率达89.4%;碱催化环化反应为一级反应,当溴化正丁基吡啶作增敏剂时,该反应的表观活化能将从161.9 KJ/mol降至18.07KJ/mol。The cyclization reaction and kinetic character of 2′-hydroxychalcone under alkaline with N-alkylpyridinium bromide had been researched.The results showed that n-butylpyridinium bromide could effective enhance the sodium hydroxide to catalyze 2′-hydroxychalcone converting into flavanone.When the reaction temperature was 20℃ and reaction time was 2 h,the yield of flavanone production was 89.4%.The cyclization reaction was first reaction.The reaction activity energy was decreased from 161.9 KJ/mol to 18.07 KJ/mol with n-butylpyridinium bromide as sensitizer.

关 键 词：溴化正丁基吡啶 增敏剂 2'-羟基查耳酮 环化反应 

分 类 号：O622.4[理学—有机化学]