胎儿脐血染色体产前诊断177例临床分析  

Clincal analysis of chromosomal karyotypes in 177 fetal cord blood

作　　者：严育宏[1] 叶雪萍[1] 周丽霞[1] 唐少华[1] 杨雪梅[1] 

机构地区：[1]温州市第二人民医院妇产科,浙江325000

出　　处：《中国优生与遗传杂志》2011年第1期35-36,52,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨胎儿脐血染色体分析在产前诊断中的应用价值。方法对孕23-38周,具有脐带血穿刺指征者177例,行脐带血穿刺术进行染色体核型分析。结果发现16例异常核型,异常率9.04%(16/177);异常核型以三体型为主,占62.5%(10/16);发生穿刺并发症7例,发生率3.95%。结论胎儿染色体分析是必要、安全可靠的产前诊断技术之一,可以满足大孕周孕妇进行产前诊断的需要,联合孕中期血清学筛查及产前B超检查可提高胎儿异常染色体核型的检出率。Objective： To investigate the value of chromosomal karyotypes of fetal cord blood for prenatal diagnosis.Methods： 177 pregnant women with the indications of prenatal diagnosis during 23 ～ 38 gestation weeks,fetal chromosomal karyotypes were analyzed with cord puncture.Results： 16 cases choromosomal abnormalities were detected and the detective rate was 9.04% （16 /177） ;10 cases were numeric abnormalities （10 /16）.7 cases had complication,and the rate was 3.95% （7 /177）.Conclusion： Cord blood for prenatal diagnosis of chromosomal diseases is necessary,safe and reliable;it meet the requirements of the pregnant woman during 23 ～ 38 weeks gestational weeks,prenatal serum screening and antenatal ultrasound screening can increase the diagnostic rate of choromosomal abnormalities.

关 键 词：产前诊断 脐血 染色体核型 

分 类 号：R714.55[医药卫生—妇产科学]