手性β-氨基醇的简捷合成及其不对称催化反应  

Convenient Synthesis of Chiral β-Amino Alcohols and Their Asymmetric Catalytic Reactions

作　　者：潘圣强[1] 张从海[1] 李烨[1] 严胜骄[1] 林军[1] 

机构地区：[1]云南大学化学科学与工程学院教育部自然资源药物化学重点实验室,昆明650091

出　　处：《有机化学》2011年第2期193-196,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.20562014;30860342)资助项目

摘　　要：从易得原料D-苯甘氨酸出发,经酯化、N-烷基化及还原等三步反应合成了五个手性β-氨基醇5和6.以此为手性配体,对催化芳香醛的不对称烯丙基化反应进行了初步研究,显示了中等程度的立体选择性.Chiral β-amino alcohols 5 and 6 were prepared efficiently from D-phenylglycine through esterification,N-alkylation and reduction reactions.By using these compounds as the chiral ligand,preliminary study on asymmetric allylation reactions of aromatic aldehyde was carried out,in which the moderate enantioselectivities were achieved.

关 键 词：氨基醇 芳香醛 不对称加成 烯丙基化反应 

分 类 号：O621.25[理学—有机化学]