N-酰化低聚壳聚糖衍生物还原能力的研究  

Power Reducing of N-acyl Chitosan Oligosaccharide

作　　者：孙涛[1] 银旭红[1] 康永峰[1] 邵则淮[1] 翁文荣[1] 

机构地区：[1]上海海洋大学食品学院,上海201306

出　　处：《天然产物研究与开发》2011年第1期98-100,130,共4页Natural Product Research and Development

基　　金：上海市教育委员会科研项目(07ZZ134);上海市教委重点学科建设项目专项基金(J50704)

摘　　要：对低聚壳聚糖进行N-酰化改性,制得取代度相同的N-马来酰低聚壳聚糖(NMCOS),N-琥珀酰低聚壳聚糖(NSCOS),N-邻苯二甲酰低聚壳聚糖(NPCOS),其中NMCOS1、NSCOS1、NPCOS1的取代度均为0.25;NMCOS2、NSCOS2、NPCOS2的取代度均为0.49。考察了6种N-酰化低聚壳聚糖衍生物的还原能力。结果表明:当取代度相同时,N-邻苯二甲酰低聚壳聚糖的还原能力最强,其次是N-马来酰低聚壳聚糖,N-琥珀酰低聚壳聚糖的还原能力最差。这可能是由取代基的性质不同所致。N-maleoyl chitosan oligosaccharide （ NMCOS ）, N-succinyl chitosan oligosaccharide （ NSCOS ） and N-phthaloyl chitosan oligosaccharide （NPCOS） with the same substituting degree were prepared by N-acylation of chitosan oligosaecharide. The substituting degrees of NMCOS1, NSCOS1 and NPCOS1 were 0.25. The substituting degrees of NMCOS2, NSCOS2, and NPCOS2 were 0.49. Their power reducing were evaluated and the results showed the order of the power reducing of the N-aeyl chitosan oligosaccharide with the same substituting degrees is NPCOS 〉 NMCOS 〉 NS- COS. That may be related to the properties of the substituting groups.

关 键 词：低聚壳聚糖 N-酰化 取代度 还原能力 

分 类 号：Q58[生物学—生物化学] R284.3[医药卫生—中药学]