Current advances in the application of proteomics in apoptosis research  

作　　者：WANG LiShun & CHEN GuoQiang Department of Pathophysiology,Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China E-Institutes of Shanghai Municipal Education Commission Chemical Biology Division,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China 

出　　处：《Science China(Life Sciences)》2011年第3期209-219,共11页中国科学（生命科学英文版）

基　　金：supported in part by the Ministry of Science and Technology of China(Grant Nos. 2006CB910104,2006AAZ105 and 2009CB918404);the National Natural Science Foundation of China(Grant Nos. 30630034,90813034 and 81071668);the Shanghai Science and Technology Commission(Grant Nos. 08JC1413700 and 07QA14041);the Shanghai Municipal Education Commission(Grant No. E09013)

摘　　要：Apoptosis,or programmed cell death,is a complex,genetically-determined process involved in the development and maintenance of homeostasis in multicellular organisms.Dysregulation of apoptosis has been implicated in a number of diseases,including cancer and autoimmune disease.Thus,the investigation of apoptotic regulation has evoked considerable interest.Many apoptotic proteins have been shown to be post-translationally modulated,such as by protein cleavage,translocation,protein-protein interaction,and various post-translational modifications,which fall precisely within the range of proteomic analysis.Recently,contemporary proteomic technologies have achieved significant advances and have accelerated research in functional and chemical proteomics,which have been applied to the field of apoptosis research and have the potential to be a driving force for the field.This review highlights some of the major achievements in the application of proteomics in apoptosis research and discusses new directions and challenges for the near future.Apoptosis,or programmed cell death,is a complex,genetically-determined process involved in the development and maintenance of homeostasis in multicellular organisms.Dysregulation of apoptosis has been implicated in a number of diseases,including cancer and autoimmune disease.Thus,the investigation of apoptotic regulation has evoked considerable interest.Many apoptotic proteins have been shown to be post-translationally modulated,such as by protein cleavage,translocation,protein-protein interaction,and various post-translational modifications,which fall precisely within the range of proteomic analysis.Recently,contemporary proteomic technologies have achieved significant advances and have accelerated research in functional and chemical proteomics,which have been applied to the field of apoptosis research and have the potential to be a driving force for the field.This review highlights some of the major achievements in the application of proteomics in apoptosis research and discusses new directions and challenges for the near future.

关 键 词：apoptosis PROTEOMICS small compound ONCOGENE tumor suppressor 

分 类 号：Q25[生物学—细胞生物学]