点状掌跖角化病伴高血压-家系遗传分析  

Genetic analysis for a family with punctate palmoplantar keratodermas complicated with hypertension

作　　者：王艳鸽[1] 赵昆朋[1] 董烁[1] 

机构地区：[1]河南大学医学院细胞生物学与遗传学教研室,河南开封475004

出　　处：《河南大学学报（医学版）》2011年第1期66-69,共4页Journal of Henan University:Medical Science

摘　　要：目的：对一伴高血压的点状掌跖角化病家系进行分析。方法：对患者家系进行家系调查和分析,观察患者症状,对患者进行医院常规检查。结果：家系中有11人为点状掌跖角化病患者,所有患者皮损均局限于手足部位,发病年龄28岁到55岁,5人伴有高血压及多汗。结论：点状掌跖角化病是一种具有高度外显率的常染色体显性遗传性皮肤病。发病年龄10~55岁,该病以双掌跖部角化过度为特征,呈现典型的遗传早现现象,并可伴有高血压发生,存在遗传异质性。Objective：To analyze a family with punctate palmoplantar keratodermas complicated with hypertension.Methods：The family tree was investigated and analyzed,the patients＇ symptoms were observed and the patients were instructed to have general checkup in hospitals regularly.Results： There are 11 people suffering from punctate palmoplantar keratodermas,all the patients＇ skin damage are restricted on limbs parts,the occurrence of the age is from 28 to 55 years old,5 people with hypertension and sweaty.Conclusion： Punctate palmoplantar keratodermas is caused by autosomal dominant inheritance,and has the genetic heterogeneity and genetic anticipation phenomenon.The disease with the ministry of excessive angular striker characteristics and the occurrence of the age is from 10 to 55 years old frequently complicated with hypertension.There exists genetic heterogeneity.

关 键 词：点状掌跖角化病 高血压 遗传分析 

分 类 号：R363.2[医药卫生—病理学]