DNA-PKcs表达与乳腺癌临床病理特征关系的研究  

Expression of DNA-PKcs and its clinicopathological significance in invasive breast cancer

作　　者：吴鸿雁[1] 余慧萍[1] 樊祥山[1] 孟凡青[1] 周强[1] 

机构地区：[1]南京大学医学院附属鼓楼医院病理科,江苏南京210008

出　　处：《现代肿瘤医学》2011年第3期465-467,共3页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:30371830);南京市科技发展计划项目(编号:200601050);南京市医学科技发展课题(编号:YKK05094)

摘　　要：目的:研究DNA依赖蛋白激酶催化亚单位(DNA-PKcs)表达与浸润性乳腺癌临床病理特征的关系。方法:应用组织芯片技术和免疫组织化学方法检测101例浸润性乳腺癌中DNA-PKcs以及ER、PR、c-erbB-2的表达情况,采用χ2检验及Spearman秩和相关检验分析结果。结果:DNA-PKcs表达与浸润性乳腺癌的肿瘤大小、淋巴结转移数量、TNM分期均呈负相关(分别为r=-0.319,P=0.001;r=-0.378,P=0.000;rs=-0.428,P=0.000);与ER表达呈正相关(rs=0.279,P=0.005);与患者年龄、肿瘤组织学分级、及PR、c-erbB-2表达的关系无统计学意义(P>0.05)。结论:DNA-PKcs低表达与浸润性乳腺癌的进展及淋巴结转移关系密切,有可能成为预测乳腺癌预后重要的生物学指标。Objective：To investigate the expression of DNA-PKcs and its relationship with clinicopathological characteristics in invasive breast cancer.Methods：DNA-PKcs and ER,PR,c-erbB-2 protein expression were assessed on a tissue microarray containing 101 invasive breast cancer cases.Furthermore,age,tumor size,TNM staging,differentiation,lymph node metastasis and so on were analyzed.Results：The expression intensity of DNA-PKcs protein in invasive breast cancer was significantly associated with tumor size（rs =-0.319,P=0.001）,lymph node metastasis（rs =-0.378,P=0.000）,and TNM stage（rs =-0.428,P=0.000）.Furthermore,DNA-PKcs expression has a positive relationship with the expression of ER（rs =0.279,P=0.005）.However,there was no significant relationship between DNA-PKcs expression and age,differentiation and expression of PR,c-erbB-2 in tumor cells.Conclusions：Low or negative expression of DNA-PKcs show poor prognosis and lymph node metastasis potential and it can be a prognostic marker of clinical outcome in breast cancer.

关 键 词：DNA-PKCS 乳腺癌/病理学 淋巴结转移 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]