云南高校图书馆联盟文献共享服务平台- DNA-PKCS

DNA-PKCS: 作品数：145被引量：391H指数：7; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：周平坤徐勤枝安静隋建丽王豫更多>>; 相关机构：军事医学科学院南华大学华中科技大学山东大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划广东省医学科学技术研究基金更多>>

DNA-PKcs Phosphorylates Cofilin2 to Induce Endothelial Dysfunction and Microcirculatory Disorder in Endotoxemic Cardiomyopathy: 《Research》2024年第4期514-532,共19页Yingzhen Du Pingjun Zhu Yukun Li Jiachi Yu Tian Xia Xing Chang Hang Zhu Ruibing Li Qingyong He; supported by grants from the NSFC(nos.82200091,82370083,81900252,82000537,and 82170241).; The presence of endotoxemia is strongly linked to the development of endothelial dysfunction and disruption of myocardial microvascular reactivity.These factors play a crucial role in the progression of endotoxemic ca...; 关键词：SUSTAINED DAMAGE inhibited

山萘酚逆转肝癌耐药细胞Bel-7402/5-Fu的作用机制研究: 《天津医药》2024年第9期900-906,共7页梁大敏杨正久张子萍钱静毛朝坤; 遵义市科技与大数据局基金资助项目[遵市科合HZ字(2022)151号,遵市科合社字(2018)41号]。; 目的探讨山萘酚(KAE)对肝癌耐药细胞Bel-7402/5-Fu功能的影响。方法采用KAE处理Bel-7402/5-Fu细胞,将细胞分为对照组和药物组(0.064、0.320、1.600、8、40、200μmol/L KAE);根据干扰DNA依赖性激酶催化亚基(DNA-PKcs)、加入蛋白酶体抑制...; 关键词：癌肝细胞山萘酚细胞凋亡细胞周期 Bel-7402/5-Fu DNA-PKCS

Knockdown of the nucleoporin Nup50 protects cells against ionizing radiation through enhancing DNA-PKcs-mediated DNA damage repair: 《Radiation Medicine and Protection》2024年第3期194-200,共7页Zhijie Wan Jingwen Gu Songyun Zhao Hang Jia Tingting Liu Yuanyuan Chen Yanyong Yang; supported by grants from Shanghai Rising Start Program(23QA1411600);the Hainan Provincial Natural Science Foundation of China(824QN408);Three-year Action Plan for strengthening the Construction of the public health system in Shanghai(GWVI-11.2-YQ47),China.; Objective:To investigate the effect and mechanism of Nup50 on radiation-induced DNA damage repair to radiation and explore the potential role of Nup50 as radioprotective target.Methods:The Nup50 gene was knocked down ...; 关键词：damage protective P50

DNA-PKcs在DNA损伤修复中的作用及机制被引量：1: 《中国老年学杂志》2024年第5期1276-1279,共4页李炜娟梁斌黄雄峰李亮荣; 国家自然科学基金资助项目(81160342);江西省自然科学基金资助项目(20122BAB205047);江西省教育厅科技研究重点项目(GJJ208902);江西省教育厅科技研究项目(GJJ11312);抚州市科技计划项目(抚科计字[2015]13号);南昌大学抚州医学院校级科技项目(fykj202204)。; 机体在体内因素如DNA碱基错配、自身不稳定性、机体代谢产生活性氧自由基(ROS)等,体外因素如辐射、化学毒物、药物、病毒和霉菌等作用下,可以造成DNA损伤。DNA损伤有碱基损伤、错配、DNA单链或双链断裂、嘧啶二聚体形成等多种类型。其中...; 关键词：DNA损伤修复 DNA依赖性蛋白激酶亚单位(DNA-PKcs) 非同源末端连接(NHEJ) 抑制剂

结肠腺癌组织中DNA-PKcs的表达及临床意义: 《临床肿瘤学杂志》2023年第12期998-1003,共6页芮鸿庆袁立单刘健魏翠诊濮阳永强周晓华; 目的探讨DNA依赖蛋白激酶催化亚单位(DNA-PKcs)在结肠腺癌(COAD)组织中的表达特征及在COAD预后中的预测价值。方法通过GEPIA在线网站分析275例COAD组织和349例正常对照组织的DNA-PKcs表达;利用Kaplan-Meier Plotter在线网站分析DNA-PKc...; 关键词：结肠腺癌 DNA依赖蛋白激酶催化亚单位预后诊断

TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNAPKcs cytosolic retention and DNA damage被引量：1: 《Acta Pharmaceutica Sinica B》2023年第12期4823-4839,共17页Wenjun Yu Haixia Xu Zhe Sun Yuxin Du Shiqun Sun Miyesaier Abudureyimu Mengjiao Zhang Jun Tao Junbo Ge Jun Ren Yingmei Zhang; supported by the National Science Foundation of China(82130011,81770261,91749128,and 81900233);the Fundamental Research Funds for the Central Universities(2042022kf1125,China);the Outstanding Young and Middleaged Talents Training Program of Zhongnan Hospital of Wuhan University(ZNYQ2022002,China).; Clinical application of doxorubicin(DOX)is heavily hindered by DOX cardiotoxicity.Several theories were postulated for DOX cardiotoxicity including DNA damage and DNA damage response(DDR),although the mechanism(s)invo...; 关键词：DOXORUBICIN CARDIOTOXICITY DNA damage DNA damage response Mitochondrial anomalies Cardiomyocyte apoptosis TBC1D15 DNA-PKCS

Targeting DNA-PKcs promotes anti-tumoral immunity via triggering cytosolic DNA sensing and inducing an inflamed tumor immuno-microenvironment in metastatic triple-negative breast cancer: 《Genes & Diseases》2023年第5期1809-1811,共3页Chao Ma Yuanhua Qin Ying Wang Chuanliang Zhu Xingjie Gao Pingping Zhang Yupeng Gu Shuailong Zhang Jintao Lin Jiahui Wang Weifeng Mao; supported by Dalian Medical University Yingcai Project(China)to W.M.and Liaoning Provincial Program for Top Discipline of Basic Medical Sciences(China).; Triple-negative breast cancer(TNBC)is highly malignant and refractory to immunotherapy through impeding the immune cell infiltration and inflammation in the tumor microenvironment(TME).1 DNA-dependent protein kinase c...; 关键词：IMMUNITY inflammation INTERFERON

NU7026抑制DNA-PKcs对辐射旁效应中L-02细胞增殖、凋亡、抗氧化的影响: 《中南医学科学杂志》2023年第4期481-485,536,共6页万丹婷周洁朱子豪邓蒸蒸雷鹏渊黄波; 国家自然科学基金项目(81272994);湖南省教育厅科学研究重点项目(19A429);湖南省自然科学基金面上项目(2021JJ30592);湖南省卫生健康委科研计划项目(D202309037942)。; 目的探讨NU7026抑制DNA-PKcs对辐射旁效应中L-02细胞增殖、凋亡、抗氧化的影响。方法构建辐射旁效应模型。实验分为空白组(阴性对照)、旁效应组(辐射条件培养液处理)、联合组(辐射条件培养液+NU7026)、辐照组(直接辐照)。采用MTT法、克...; 关键词：NU7026 DNA-PKCS 辐射旁效应 L-02细胞细胞增殖

Topoisomerase I Inhibition Radiosensitizing Hepatocellular Carcinoma by RNF144A-mediated DNA-PKcs Ubiquitination and Natural Killer Cell Cytotoxicity: 《Journal of Clinical and Translational Hepatology》2023年第3期614-625,共12页Chiao-Ling Tsai Po-Sheng Yang Feng-Ming Hsu Ann-Lii Cheng Wan-Ni Yu Jason Chia-Hsien Cheng; National Taiwan University Hospi-tal(NTUH 106-M3649,107-M4030,108-M4213,109-M4767 and 110-M5149);the Ministry of Science and Technology of Taiwan(MOST 106-2314-B-002-063-,107-2314-B-002-097-and 108-2314-B-002-046-).; Background and Aims: Topoisomerase I (TOP1) partici-pates the repair of DNA double-strand breaks (DSBs) upon radiation therapy (RT). RNF144A mediates ubiquitination of catalytic subunit of DNA protein kinase (DNA-PKcs...; 关键词：Hepatocellular carcinoma RADIOTHERAPY DNA topoisomerase I Li-potecan RNF144A.

Ubiquitination and degradation of SIK2 by DNA-PKcs deficiency promote radiation-induced mitotic catastrophe: 《Genes & Diseases》2023年第2期313-316,共4页Jiaojiao Zhu Ying Zhang Ziyan Yan Jianxiao Wang Ping Wang Xinxin Liang Yuhao Liu Xingkun Ao Maoxiang Zhu Pingkun Zhou Yongqing Gu; funded by grants from the National Natural Science Foundation of China(31470827,81773359,82073488,31870847 and 3127894).; Salt-inducible kinase 2 (SIK2) is a member of the AMP-activated serine/threonine kinase family. It has been reported that inhibition of SIK2 can enhance the cytotoxicity of paclitaxel,1 promote premitotic apoptosis, a...; 关键词：CATASTROPHE SIK2 damage

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