NF-kB in the regulation of epithelial homeostasis and inflammation  

出　　处：《Cell Research》2011年第1期146-158,共13页细胞研究（英文版）

摘　　要：The IKB kinase/NF-kB signaling pathway has been diseases. Increased activation of NF-kB is often detected implicated in the pathogenesis of several inflammatory in both immune and non-immune cells in tissues affected by chronic inflammation, where it is believed to exert detrimental functions by inducing the expression of proinflammatory mediators that orchestrate and sustain the inflammatory response and cause tissue damage. Thus, increased NF-KB activation is considered an important pathogenic factor in many acute and chronic inflammatory disorders, raising hopes that NF-kB inhibitors could be effective for the treatment of inflammatory diseases. However, ample evidence has accumulated that NF-kB inhibition can also be harmful for the organism, and in some cases trigger the development of inflammation and disease. These findings suggested that NF-kB signaling has important functions for the maintenance of physiological immune homeostasis and for the prevention of inflammatory diseases in many tissues. This beneficial function of NF-kB has been predominantly observed in epithelial cells, indicating that NF-kB signaling has a particularly important role for the maintenance of immune homeostasis in epithelial tissues. It seems therefore that NF-kB displays two faces in chronic inflammation： on the one hand increased and sustained NF-kB activation induces inflammation and tissue damage, but on the other hand inhibition of NF-kB signaling can also disturb immune homeostasis, triggering inflammation and disease. Here, we discuss the mechanisms that control these apparently opposing functions of NF-kB signaling, focusing particularly on the role of NF-kB in the regulation of immune homeostasis and inflammation in the intestine and the skin.

关 键 词：NF-KB signal transduction INFLAMMATION mouse models of human disease epithelial homeostasis 

分 类 号：S858[农业科学—临床兽医学] Q813.11[农业科学—兽医学]