Acrosin structure-based design,synthesis and biological activities of 7-azaindol derivatives as new acrosin inhibitors  

作　　者：Jun Hang Jiang Xue Fei Liu Can Hui Zhen You Jun Zhou Ju Zhu Jia Guo Lv Chun Quan Sheng 

机构地区：[1]Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

出　　处：《Chinese Chemical Letters》2011年第3期272-275,共4页中国化学快报（英文版）

基　　金：supported by the Shanghai Family Planning Commission Research Fund(No2007JG02);Shanghai Leading Academic Discipline Project(NoB906)

摘　　要：A series of 7-azaindol derivatives were designed based on the homologous 3D model of human acrosin.These compounds were synthesized and evaluated for their human acrosin inhibitory activities in vitro.Compounds 7a,7i,7j,7k and 7n showed highly inhibitory activity against human acrosin.The three-dimensional structure-activity relationship was investigated through a CoMFA model,which provided valuable information to further study of potential human acrosin inhibitors.A series of 7-azaindol derivatives were designed based on the homologous 3D model of human acrosin.These compounds were synthesized and evaluated for their human acrosin inhibitory activities in vitro.Compounds 7a,7i,7j,7k and 7n showed highly inhibitory activity against human acrosin.The three-dimensional structure-activity relationship was investigated through a CoMFA model,which provided valuable information to further study of potential human acrosin inhibitors.

关 键 词：Rational design AZAINDOLE SYNTHESIS ACROSIN COMFA 

分 类 号：TQ465.92[化学工程—制药化工] S823.34[农业科学—畜牧学]