ACROSIN

作品数：5被引量：92H指数：3
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相关领域：医药卫生农业科学更多>>
相关作者：刘建兵毛海涛更多>>
相关机构：第二军医大学浙江大学上海交通大学更多>>
相关期刊：《Asian Journal of Andrology》《Chinese Journal of Structural Chemistry》《Acta Biochimica et Biophysica Sinica》《Chinese Chemical Letters》更多>>
相关基金：上海市教育委员会重点学科基金国家重点基础研究发展计划更多>>
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Low levels of PRSS37 protein in sperm are associated with many cases of unexplained male infertility被引量：1
《Acta Biochimica et Biophysica Sinica》2016年第11期1058-1065,共8页Jianbing Liu Chunling Shen Weimin Fan Yan Chen Aijun Zhang Yun Feng Zheng Li Ying Kuang ZhugangWang 
This work was supported by the grants from National Natural Science Foundation of China （No. 81430028）, Ministry of Science and Technology of China （No. 2011BAI15B02）, Science and Technology Commission of Shanghai Municipality （Nos. 13DZ2280600 and 15DZ2290800）, and E-Institutes of Shanghai Municipal Education Commission （No. E03003）.
PRSS37, a putative trypsin-like serine protease, is highly conserved during mammalian evolution as revealed by multiple sequence alignment. Mice deficient for Prss37 gene exhibit male infertility, but their mating beh...
关键词：PRSS37 ACROSIN ADAM2 semen analysis unexptained male infertility 
Synthesis and Crystal Structure of a Novel Ethyl 5-(4-(2-Phenylacetamido)phenyl)-1H-pyrazole-3-carboxylate as an Acrosin Inhibitor被引量：2
《Chinese Journal of Structural Chemistry》2011年第11期1604-1608,共5页祁晶晶 周有骏 刘雪飞 丁莉莉 郑灿辉 盛春泉 吕加国 朱驹 
supported by the Science and technology support program of Jiangsu Province (2010, BE2010682)
The title compound （ethyl5-（4-（2-phenylacetamido）phenyl）-lH-pyrazole-3-carboxylate, C20H19N3O3） was synthesized by the reaction of Claisen condensation, cyclization, reduction and acylation. The structure was ch...
关键词：ethyl 5-（4-（2-phenylacetamido）phenyl）-1H-pyrazole-3-carboxylate crystal structure acrosin inhibitor 
Acrosin structure-based design,synthesis and biological activities of 7-azaindol derivatives as new acrosin inhibitors被引量：3
《Chinese Chemical Letters》2011年第3期272-275,共4页Jun Hang Jiang Xue Fei Liu Can Hui Zhen You Jun Zhou Ju Zhu Jia Guo Lv Chun Quan Sheng 
supported by the Shanghai Family Planning Commission Research Fund(No2007JG02);Shanghai Leading Academic Discipline Project(NoB906)
A series of 7-azaindol derivatives were designed based on the homologous 3D model of human acrosin.These compounds were synthesized and evaluated for their human acrosin inhibitory activities in vitro.Compounds 7a,7i,...
关键词：Rational design AZAINDOLE SYNTHESIS ACROSIN COMFA 
Relationship between acrosin activity of human spermatozoa and oxidative stress被引量：27
《Asian Journal of Andrology》2004年第4期313-318,共6页Adel A.Zalata Ashraf H.Ahmed Shyam S.R.Allamaneni Frank H.Comhaire Ashok Agarwal 
Aim: To study the association between seminal oxidative stress and human sperm acrosin activity. Methods: It is a prospective study consisting of 30 infertile men and 12 fertile normozoospermic volunteers. A full hist...
关键词：ACROSIN gelatinolysis reactive oxygen species lipid peroxidation LEUKOCYTOSPERMIA SPERMATOZOA oligo-astheno-teratozoospermia INFERTILITY 
Determination of sperm acrosin activity for evaluation of male fertility被引量：61
《Asian Journal of Andrology》2000年第3期229-232,共4页Yun-HeCUI Rui-LanZHAO QiangWANG Zi-YingZHANG 
Aim: To investigate a simple method for assaying acrosin activity for the evaluation of male fertility. Methods:The acrosin activity of 7.5 × 10~6 sperm without seminal plasma and acrosin activity inhibitors was assa...
关键词：SPERM acrosin assay male fertility 
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