贵阳地区孕期夫妇地中海贫血血液学筛查的研究  

Antenatal Screening of Thalassemia in Guiyang Area

作　　者：单可人[1] 何燕[1] 窦友莲[2] 钟复光[1] 徐德明[1] 惠春林[2] 刘琦[2] 

机构地区：[1]贵阳医学院分子生物学研究室 [2]贵阳医学院附院产科

出　　处：《贵州医药》1999年第4期314-315,共2页Guizhou Medical Journal

基　　金：贵州省教委基金

摘　　要：目的：对贵阳地区孕期夫妇进行地中海贫血（以下简称地贫）血液学筛查，预防和控制地贫重症患儿的出生。方法：采用一管定量筛查法及HbA、HbF定量法。结果：在贵阳医学院附院产科围产期检查的324例孕妇及其配偶进行血液学筛查，检出地贫阳性病例14例，其中二对孕期夫妇双方均为阳性，患病率为4．32％。结论：这是首次在贵阳地区进行的筛查研究工作。为产前基因诊断奠定了基础。Objective. To screen pregnant women and their hus-bands to investigate the carrier rate of thalassemia in general popula-tion. Methods. HbA2 and HbF quantitative analysis and screening ofone tube quantity. Results. Of all 324 individuals screening for thalas-semia 14. cases were found. the two couples of them were positivethalassemia. The incidence of this disease was 4. 32%. Conclusion.This work build the foundation for prenatal diagnosis of the thalasse-mia.

关 键 词：地中海贫血 遗传筛查 血液学筛查 产前诊断 

分 类 号：R714.55[医药卫生—妇产科学] R556.61[医药卫生—临床医学]