Simulation of tumor microvasculature and microenvironment response to anti-angiogenic treatment by angiostatin and endostatin  

作　　者：吴洁 丁祖荣 蔡彦 许世雄 赵改平 龙泉 

机构地区：[1]School of Naval Architecture,Ocean and Civil Engineering,Shanghai Jiaotong University [2]Department of Mechanics and Engineering Science,Fudan University [3]School of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology [4]Brunel Institute for Bioengineering,Brunel University

出　　处：《Applied Mathematics and Mechanics(English Edition)》2011年第4期437-448,共12页应用数学和力学（英文版）

基　　金：supported by the National Natural Science Foundation of China (No. 10772051);the Postdoctral Foundation of China (No. 20100470702)

摘　　要：The effects of anti-angiogenesis treatment by angiostatin and endostatin on normalization of tumor microvasculature and microenvironment are investigated, based on mathematical modeling and numerical simulation of tumor anti-angiogenesis and tumor haemodynamics. The results show that after anti-angiogenesis treatment： （i） the proliferation, growth, and branching of neo-vessels are effectively inhibited, and the extent of vascularization in tumors is accordingly reduced. （ii） the overall blood perfusion inside of tumor is declined, the plateau of tumor interstitial fluid pressure （IFP） is relieved, the interstitial fluid oozing out from the tumor periphery into the surrounding normal tissue is reduced, the reduction of overall extravasation across vasculature to tumor interstium is much less than the decreased overall blood perfusion, due to the decline of IFP, the intravasations is remarkablely effected by the change, in some cases there are no intravasation flow appear.The effects of anti-angiogenesis treatment by angiostatin and endostatin on normalization of tumor microvasculature and microenvironment are investigated, based on mathematical modeling and numerical simulation of tumor anti-angiogenesis and tumor haemodynamics. The results show that after anti-angiogenesis treatment： （i） the proliferation, growth, and branching of neo-vessels are effectively inhibited, and the extent of vascularization in tumors is accordingly reduced. （ii） the overall blood perfusion inside of tumor is declined, the plateau of tumor interstitial fluid pressure （IFP） is relieved, the interstitial fluid oozing out from the tumor periphery into the surrounding normal tissue is reduced, the reduction of overall extravasation across vasculature to tumor interstium is much less than the decreased overall blood perfusion, due to the decline of IFP, the intravasations is remarkablely effected by the change, in some cases there are no intravasation flow appear.

关 键 词：solid tumor microenvironment normalization numerical simulation ANTI-ANGIOGENESIS 

分 类 号：R730.5[医药卫生—肿瘤]