产前筛查中位数和体重修正结果的临床意义  

The median and weight correction of prenatal screening and clinical significance of the result

作　　者：许晓红[1] 邓松华[2] 

机构地区：[1]安徽医科大学妇幼保健临床学院,合肥市妇幼保健院,合肥230061 [2]安徽医科大学病理生理学教研室,合肥230032

出　　处：《安徽医科大学学报》2011年第2期158-161,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省自然科学基金(编号:090413136);安徽省教育厅自然科学重点科研项目(编号:KJ2010A177)

摘　　要：目的探索合肥妇幼保健院产前筛查实验室中位数修正和体重修正结果。方法在合肥市妇幼保健院参加产前筛查且孕周为14~20＋6周的孕妇。选择甲胎蛋白、游离人绒毛膜促性腺激素作为血清标志物,采用时间分辨技术,统计中位数和体重中位数并分析结果。结果 2T-Risk软件计算阳性率为2.76%,换用中位数后筛查阳性率为5.03%,体重修正后筛查阳性率为5.47%,经验证,修正后确诊标本均能检出。结论建议每个实验室建立中位数和体重方程,提高筛查效率。Objective To explore the result of the median and weight correction in the screening laboratories of Hefei Maternal and Child Care Service Centre.Methods Alpha-fetoprotein（AFP）and free β-subunit of human chorionic gonadotrophin（Free-β-hCG）were used as serum markers in this study.Time-resolved fluoroimmunoassay system（PE Wallac 1420） was used to detect the maternal serum markers and at about 14~20＋6 weeks of gestation.Then statistical the median and the weight.Results Use 2T software,the positive rate was 2.76%,and 5.03% after a change on the median.The positive rate rose to 5.47% after revising the weight.All the samples diagnosed had been figger out.Conclusion Each laboratory should establish its own median and weight equation in order to improve the effectiveness of screening.

关 键 词：唐氏综合征 遗传筛查 体重 

分 类 号：R742.89[医药卫生—神经病学与精神病学] R714.55[医药卫生—临床医学]