急性白血病细胞的遗传学改变及其临床意义  

Cytogenetic analysis and its clinical significance in childhood acute leukemia

作　　者：柴忆欢[1] 王易[1] 何海龙[1] 徐杰[1] 王津媛[1] 李祯萍[1] 彭惠兰[1] 朱玲琍[1] 何军[2] 何亚香[2] 

机构地区：[1]苏州医学院附属儿童医院内科血液组,215003 [2]苏州医学院附属儿童医院,215003

出　　处：《中华儿科杂志》1999年第10期619-621,共3页Chinese Journal of Pediatrics

摘　　要：目的　探讨小儿急性白血病（ＡＬ） 细胞的遗传学改变及其临床意义。方法　采用细胞遗传学技术对８７ 例小儿ＡＬ进行染色体检查和临床治疗观察。结果　８７ 例ＡＬ细胞核型异常检出率为６２％ （５４／８７），结构异常与白血病类型有特殊的对应关系；核型正常组缓解率高于核型异常组（ Ｐ＜０－０５），核型正常、超二倍体及ｔ（１５；１７） 易位者疗效较好，而伴ｔ（９ ；２２） 、ｔ（４；１１） 及ｔ（８；２１） 易位者疗效较差；缓解期染色体仍为异常核型者常表示复发前兆。结论　细胞遗传学检查对小儿ＡＬ的诊断分型、指导治疗以及预后判断有重要的临床意义。Objective To study the cytogenetic features and the clinical significance in childhood acute leukemia(AL) Methods Cytogenetic analyses were performed in 87 children with AL Results Chromosome aberrations were identified in 62% of AL cases Chromosome translocations were specifically associated with AL subtypes The complete remission rates of AL were significantly higher in patients with the normal karyotype than patients with the abnormal karyotype ( P <0 05) Patients with the normal karyotype, ultratwiceploid and t(15;17) showed the best therapeutic effect, while patients with the abnormal karyotype,t(9;22),t(4;11)and t(8;21) manifested the poor therapeutic effect It might be a sign of relapse that the abnormal karyotype persisted during the period of AL remission Conclusion Cytogentic analysis in children with AL was significant in diagnosis, classification, treatment as well as evaluation of prognosis

关 键 词：白血病 细胞遗传学 急性 

分 类 号：R733.710.2[医药卫生—肿瘤]