喹诺酮类抗菌药物研究新进展  

Progress in research on quinolone antibacterials

作　　者：蒋晓磊[1] 崔玉彬[1] 曹胜华[1] 

机构地区：[1]中国医药集团总公司四川抗菌素工业研究所,成都610052

出　　处：《中国抗生素杂志》2011年第4期255-263,共9页Chinese Journal of Antibiotics

摘　　要：本文简述了喹诺酮类药物近几年的研究进展,分为上市药物、临床试验药物和未来发展趋势三部分,对目前处于临床研究阶段的药物做了重点讲述,其中delafloxacin是最有希望的喹诺酮类候选药物,同时介绍了喹诺酮类抗菌药物的未来发展方向,即侧链修饰、喹诺酮类似物、喹诺酮杂合物和TB药物与喹诺酮轭合物。This article has reviewed progress in research on quinolone antibacterials in recent years,which consisted of newly launched products, agents in clinical trials and future development of this kind of drugs.It focused on some clinical promising candidates. Among these drugs, delafloxacin would be the most potential candidate. Moreover it introduced new fields of the future development, including modifying side chain, quinolone-like compounds, antibacterial quinolone hybrids and anti-TB quinolone-drug conjugates.

关 键 词：喹诺酮类 抗菌谱 抗菌活性 

分 类 号：R978.1[医药卫生—药品]