蓖麻油缓释微囊的研制  

Study on the Preparation of Sustained-release Castor Oil Microcapsule

作　　者：常明[1] 岳红坤[1] 牟微[1] 李慧[1] 郭敬敬[1] 

机构地区：[1]石家庄学院化工学院,河北石家庄050035

出　　处：《安徽农业科学》2011年第10期6085-6087,共3页Journal of Anhui Agricultural Sciences

摘　　要：[目的]对蓖麻油进行微胶囊化,制成蓖麻油缓释微胶囊。[方法]运用复凝聚法,以明胶和阿拉伯胶为囊材,蓖麻油为囊心物制备微囊。借助显微镜观察微囊形态;通过紫外分光光度计进行蓖麻油含量测定;以水为溶出介质考察该制剂的体外溶出情况;以包封率作为质量判定指标,采用单因素考察和正交试验优化处方工艺。[结果]蓖麻油缓释微囊的最佳制备工艺条件为:明胶和阿拉伯胶浓度皆为7.5%,甲醛用量为1.0 ml,pH值为3.80,材药比为6∶1。按该处方制得的微囊囊型圆整光滑,载药量较高,并具有一定的缓释效果。[结论]复凝聚法可成功制备出包封率较高的蓖麻油缓释微囊,且产品稳定性良好。该法可操作性强,重复性好,有一定的实用价值。[Objective]Microencapsulation was carried out for castor oil,thus,sustained-release castor oil microcapsule was prepared.[Method]Complex coacervation method was used,and taking gelatin and Arabic gum as capsule materials,in addition,castor oil was viewed as core materials to prepare micro-capsule.The shapes of microcapsules were observed with the help of microscope,the content of castor oil was determined based on ultraviolet spectrophotometer;and dissolution rate in vitro with water were investigated.With encapsulation efficiency as quality evaluation index,furthermore,the prescription was optimized by single phoneme and orthogonal experiment.[Result]The best preparation technological conditions of sustained-release castor oil microcapsule were： the gelatin and the Arabic gum density was 7.5%,the formaldehyde amount was the 1.0 ml,pH value was 3.80,the proportion of raw material to medicine was 6∶1.According to this prescription,the shape of micro-capsule was rounding and smooth,and showed larger loading capacity,moreover,had certain sustained-release effect.[Conclusion] The duplicate condensation law may successfully prepared sustained-release castor oil microcapsule with higher entrapment rate,moreover,the product stability was good.The method had strong operability and good duplication,thus,had certain practical value.

关 键 词：蓖麻油 复凝聚法 微囊化 正交试验 

分 类 号：S37[农业科学—农产品加工]