1,3-丙二醇发酵液后提取技术研究进展  

Progress in down-stream processing of biologically produced 1,3-propanediol

作　　者：吴如春[1,2] 许赟珍[1] 刘德华[1] 

机构地区：[1]清华大学化工系应用化学研究所,北京100084 [2]广西民族大学化学与生态工程学院化学与生物转化过程新技术广西高校重点实验室,南宁530006

出　　处：《生物工程学报》2011年第3期493-501,共9页Chinese Journal of Biotechnology

基　　金：国家高技术研究发展计划(863计划)(No.2008AA05Z302)资助~~

摘　　要：1,3-丙二醇是一种重要的化工原料,以甘油或葡萄糖为原料发酵法制备1,3-丙二醇具有原料可再生、反应条件温和等优点,是近年来国内外的研究热点。由微生物发酵获得的1,3-丙二醇发酵液是含多种强极性的醇及盐类的稀溶液,这使得采用传统的分离方法难以经济、有效地的将1,3-丙二醇从发酵液中纯化出来,后提取过程成为发酵法工业化生产1,3-丙二醇的瓶颈。1,3-丙二醇后提取过程主要包括微生物菌体等高分子物质的去除,盐的去除、回收,有机物的纯化和水的去除。以下对应用于以上分离过程的技术的研究进展进行讨论,提出在该领域应该重视的发展方向。1,3-propanediol is an important raw material in chemical industry.Microbial conversion of glycerol or glucose into 1,3-propanediol has been given much attention due to its renewable resource,mild reaction conditions,and other advantages.It is a challenge to efficiently separate 1,3-propanediol from a mixture of multiple components,such as 1,3-propanediol,2,3-butanediol,water,residual glycerol,ethanol,macromolecules and salts,for the reason that 1,3-propanediol,glycerol and 2,3-butanediol are all very hydrophilic and have intense polarity.The conventional evaporation and distillation techniques used in the purification of 1,3-propanediol suffer from the problem of high energy consumption and low recovery.It makes the recovery of 1,3-propanediol from a fermentation broth become a bottleneck in industrial production.The down-stream processing of biologically produced 1,3-propanediol mainly includes the removal of protein,salts,water and other impurities.This paper analyze the research progress of these separation technologies and point out the developing direction worth further investigation.

关 键 词：1 3-丙二醇 发酵液 后提取 研究进展 

分 类 号：TQ923[轻工技术与工程—发酵工程] TQ223.162