CDX2和EGFR的表达与胃癌生物学行为关系的研究  

Study of the relationship between the expression of CDX2,EGFR and the biological behavior of gastric cancer

作　　者：方海洋[1] 李群星[2] 田君才[3] 张正坤[4] 汪龙德[2] 

机构地区：[1]甘肃省金昌市金川集团公司医院消化内科,737100 [2]甘肃中医学院附属医院消化内科,730020 [3]甘肃省酒泉市人民医院病理科,735000 [4]甘肃省酒泉市人民医院消化内科,735000

出　　处：《国际消化病杂志》2011年第2期118-120,共3页International Journal of Digestive Diseases

基　　金：甘肃省教育厅计划项目(2008-0806B-02)

摘　　要：目的探讨胃癌组织中尾型同源盒转录因子-2(CDX2)、表皮生长因子受体(EGFR)的表达与胃癌临床病理的关系。方法收集胃癌组织及相应配对癌旁组织标本各50例,采用免疫组化方法检测CDX2、EGFR的表达,分析其表达与胃癌临床病理参数的关系及意义。结果胃癌组织中CDX2和EGFR表达率分别为78.0%和52.0%,高于癌旁组织(54.0%,16.0%)(P<0.05)。CDX2表达与胃癌Lauren分型及临床分期有关(P<0.05)。EGFR表达与淋巴结转移状态及临床分期有关(P<0.05)。CDX2与EGFR在胃癌组织表达呈负相关。结论 CDX2和EGFR均参与了胃癌的发生发展。CDX2主要在肠型胃癌中表达,且可能为肠型胃癌的早期事件。EGFR的过表达可能为胃癌进展及预后较差的指标。Objective To study the relationship between expression of CDX2 and EGFR in gastric cancer tissue and clinical pathology of gastric cancer. Methods Fifty cases of gastric carcinoma and the corresponding paired adjacent tissue were collected. The expression of CDX2 and EGFR was tested using immunohistochemical method, and the relationship of its expression and clinic pathological characteristics of gastric cancer analysis. Results The expression rate of CDX2 and EGFR in gastric cancer tissues was 78.0% and 52.0%, significantly higher than adjacent tissues （54.0%, 16. 0%） （P〈0. 05）. The expression of CDX2 in gastric cancer were related with Lauren classification and clinical staging （P〈0.05）. The expression of EGFR has positive correlation with the lymph node metastasis status and the pathological stage （P〈0.05）. Conclusions Both CDX2 and EGFR are involved in the occurrence and development of gastric cancer. CDX2 is expressed mainly in the intestinaltype gastric carcinoma, and may be an early event in intestinal type gastric cancer. The overexpression of EGFR can be an index of progressing and poor prognosis in gastric cancer.

关 键 词：胃癌 免疫组化 CDX2 EGFR 

分 类 号：R735.2[医药卫生—肿瘤]