Lipid disorders and lipid peroxidation associated with the malignant transformation of colorectal adenoma  

脂代谢紊乱及脂质过氧化与结肠腺瘤恶变的关系(英文)

作　　者：Didi Tao Zhongyin Zhou Ximing Xu Hesheng Luo 

机构地区：[1]Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China [2]Cancer Center, Renmin Hospital of Wuhan University ,Wuhan 430060,China

出　　处：《The Chinese-German Journal of Clinical Oncology》2011年第5期270-273,共4页中德临床肿瘤学杂志（英文版）

基　　金：Supported in part by Natural Science Foundation of Hubei Province (No. 302-131703)

摘　　要：Objective:The aim of this study was to investigate lipid disorders and lipid peroxidation associated with the malignant transformation of colorectal adenoma.Methods:Analyses were based on data from 100 subjects with histologically confirmed adenomas(cases) and 50 adenoma-free control subjects,all of whom had colonoscopy.The subjects were divided into two groups:those with no adenoma and those with adenoma.According to subsite of adenomas the subjects with adenoma were divided into group of distal adenoma and group of proximal adenoma.According to histology of adenomas the subjects with adenoma were divided into group of villiform adenoma and group of tubular + tubulo-villous adenoma.Among the groups,the serum levels of triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),lowdensity lipoprotein cholesterol(LDL-C),and lipid peroxidation product malondialdehyde(MDA) were compared in all the patients.Results:Plasma total cholesterol and MDA level in group of adenomas were significantly higher than that in group of control subjects,but plasma HDL-C level was low in group of adenomas(P<0.05).Plasma total cholesterol and MDA levels were positively related to distal and villiform adenomas(P<0.05).Conclusion:The findings suggest that altered lipid metabolism may be differentially associated with colorectal adenomas.

关 键 词：LIPID lipid peroxidatio colorectal adenomas 

分 类 号：Q691.5[生物学—生物物理学] TS202.3[轻工技术与工程—食品科学]