基于GIS的基因表达图谱模型的建立与应用  

Research on the Gene Expression Profile Model Based on GIS

作　　者：赵龙山[1] 于小玲[1] 胡国杰[2] 吴发启[1] 魏晓妹[2] 

机构地区：[1]西北农林科技大学资源环境学院,杨凌712100 [2]西北农林科技大学水利与建筑工程学院,杨凌712100

出　　处：《中国细胞生物学学报》2011年第4期402-406,共5页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(No.40871133)资助项目~~

摘　　要：本文在合理假设的基础上,根据2010年全国研究生数学建模竞赛A题提供的数据及相关信息,在GIS的支持下构建了基因表达图谱模型(简称GEPM),并对其进行空间分析,从而达到对肿瘤识别信息基因提取的目的。结果表明,在参与分析的1 991个基因中,有7个基因可以作为肿瘤识别的信息基因;通过GIS技术构建GEPM对于肿瘤的识别与诊断是可行的。因此,通过本文的研究为基因的识别和研究提供了新的方法。In this paper, in support of GIS technology, we established gene expression profile models （in short of GEPM） and analyzed its spatial information based on the reasonable assumption, according to the dates and related information provided by the question A of 2010 National Graduate Mathematical Modeling Contest, so as to achieve extraction of informative genes which can identify tumor. The results showed that among 1 991 genes analyzed, there were 7 genes can be regarded as informative genes which could identify the tumor; It was feasible to identify and diagnose the tumor through GIS technology to build GEPM.. Therefore, this study provided a new approach to identify and study genes.

关 键 词：栅格数据 GEPM 半变异函数 GIS 肿瘤 信息基因 

分 类 号：P208[天文地球—地图制图学与地理信息工程]