晚期混合裂变产物内照射诱发大鼠外周血淋巴细胞hprt基因位点突变与染色体畸变的研究  

Study on hprt Gene Loci Mutation and ChromosomeAberration in Rat Peripheral Blood LymphocytesInduced by Delayed Fission Product Mixture

作　　者：赵经涌[1] 劳勤华[1] 徐永忠[1] 

机构地区：[1]苏州医学院放射医学系,苏州市215006

出　　处：《工业卫生与职业病》1999年第5期272-275,共4页Industrial Health and Occupational Diseases

摘　　要：应用多核细胞法研究晚期混合裂变产物内照射诱发大鼠外周血淋巴细胞ｈｐｒｔ 基因位点突变， 并与染色体畸变进行比较。结果表明， 淋巴细胞ｈｐｒｔ 基因位点突变不仅随内照射剂量增加而增加， 呈现出良好的正相关， 而且与染色体畸变之间亦呈现出较好的相关性。说明辐射诱发ｈｐｒｔ 基因位点突变和染色体畸变的剂量效应关系动力学相似。因此ｈｐｒｔ 基因位点突变有可能成为生物剂量计。The hprt geneloci mutation in rat peripheral blood lymphocytesinduced by delayedfission product mixture was studied with multinucleated cellassay , and compared with chromosome aberration. The resultsshowed that hprt gene mutant frequency (GMF) and chromosome aberra tion frequency (CAF) did not increase with the dose, but were clearly interrelated between GMF and CAF.Itconfirmed that the hprt gene mutant is similar to the chromosome aberration in the dose response relationship kinetics.

关 键 词：裂变产物内照射 hprt基因位点 突变 染色体畸变 

分 类 号：R818.03[医药卫生—放射医学]