Zuogui pills for myelinolysis in a rat model of experimental autoimmune encephalomyelitis  

作　　者：Yongping Fan Kelong Chen Kangning Li Jianping Zhou Yan Shao Hongyan Liu WenjingYang 

机构地区：[1]Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China [2]Beijing Institute of Pharmaceutical Analysis, Beijing 100035, China

出　　处：《Neural Regeneration Research》2011年第9期666-670,共5页中国神经再生研究（英文版）

基　　金：the Key Combination Program of Capital Medical Development Foundation, No. 2005-SF-I-001;the Natural Science Foundation of Beijing, No. 7102051;Beijing Science and Technology Development Foundation of Traditional Chinese Medicine, No. JJ2009-27;the National Natural Science Foundation of China, No. 81072765

摘　　要：Zuogui pills have been shown to attenuate the inflammatory reaction in a rat model of experimental autoimmune encephalomyelitis （EAE）. The present study attempted to investigate the pathology underlying the influence of Zuogui pills on myelinolysis in EAE rats. Hematoxylin-eosin and Luxol fast blue staining showed that the myelinolysis foci in the cerebrum, cerebellum, brain stem, and the spinal cord of EAE rats were significantly decreased, along with serum myelin basic protein content following treatment with Zuogui pills.Zuogui pills have been shown to attenuate the inflammatory reaction in a rat model of experimental autoimmune encephalomyelitis （EAE）. The present study attempted to investigate the pathology underlying the influence of Zuogui pills on myelinolysis in EAE rats. Hematoxylin-eosin and Luxol fast blue staining showed that the myelinolysis foci in the cerebrum, cerebellum, brain stem, and the spinal cord of EAE rats were significantly decreased, along with serum myelin basic protein content following treatment with Zuogui pills.

关 键 词：Zuogui pill PATHOLOGY multiple sclerosis experimental autoimmune encephalomyelitis PROTECTION TREATMENT neural regeneration 

分 类 号：S858.966[农业科学—临床兽医学] TN16[农业科学—兽医学]