Silencing of high mobility group A1 enhances gemcitabine chemosensitivity of lung adenocarcinoma cells  

作　　者：CAO Yuan-dong HUANG Pei-lin SUN Xin-chen MA Jun JIN Zhi-liang CHENG Hong-yan XU Rui-zhi LI Fan QIN Shu-kui DENG Yu-xia GE Xiao-lin 

机构地区：[1]Department of Oncology, Zhong Da Hospital Affiliated to Southeast University, Nanjing, Jiangsu 210009, China [2]Department of Pathology and Pathophysiology, School of Biological Science and Medical Engineering , Southeast University, Nanjing, Jiangsu 210009, China [3]School of Medicine , School of Biological Science and Medical Engineering , Southeast University, Nanjing, Jiangsu 210009, China [4]Department of Oncology, the 8 lth Hospital of People's Liberation Army, Nanjing, Jiangsu 210034, China

出　　处：《Chinese Medical Journal》2011年第7期1061-1068,共8页中华医学杂志（英文版）

摘　　要：Background The high mobility group A1 （HMGA1） proteins are architectural transcription factors found to be overexpressed in iung adenocarcinoma. Lentivirus-mediated RNA interference （RNAi） technology is a powerful tool for silencing endogenous or exogenous genes in human cancer cells. Our preliminary study shows that gemcitabine inhibits growth of the human lung cancer cell line SPCA-1 and induces apoptosis, and this effect might link with down-regulation of HMGA1 expression. This study aimed to investigate the chemosensitivity change of the lung adenocarcinoma cells SPCA-1 after HMGA1 inhibition by Jentivirus-mediated RNAi.Background The high mobility group A1 （HMGA1） proteins are architectural transcription factors found to be overexpressed in iung adenocarcinoma. Lentivirus-mediated RNA interference （RNAi） technology is a powerful tool for silencing endogenous or exogenous genes in human cancer cells. Our preliminary study shows that gemcitabine inhibits growth of the human lung cancer cell line SPCA-1 and induces apoptosis, and this effect might link with down-regulation of HMGA1 expression. This study aimed to investigate the chemosensitivity change of the lung adenocarcinoma cells SPCA-1 after HMGA1 inhibition by Jentivirus-mediated RNAi.

关 键 词：RNA  small interfering high mobility group AI proteins APOPTOSIS CHEMOSENSITIVITY 

分 类 号：R[医药卫生]