Two new cucurbitane triterpenoids from Momordica charantia L.  

作　　者：Jia Qing Cao Yu Zhang Jiong Mo Cui Yu Qing Zhao 

机构地区：[1]School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China [2]Yanbian University Health Science Center, Yanbian University, Yanji 133000, China

出　　处：《Chinese Chemical Letters》2011年第5期583-586,共4页中国化学快报（英文版）

基　　金：supported by E&T Modern Center for Natural Products of Liaoning Province of China (No.2008402021)

摘　　要：Two new cucurbitane-type triterpenoids,（23E）-5β,19-epoxycucurbita-6,23,25-triene-3β-ol（1） and（19R,23E）-5/β,19-epoxy- 19-ethoxycucurbita-6,23-diene^3β,25-diol（2）,together with three known compounds,have been isolated from the fruit of Momordica charantia L.Their structures were determined on the basis of spectral analysis.Their cytotoxic activity was tested on 5 cancer cell lines,MCF-7,HepG2,Dul45,Colon205 and HL-60 by MTT assay.Compounds 1,3 and 4 showed weak cytotoxicity.Two new cucurbitane-type triterpenoids,（23E）-5β,19-epoxycucurbita-6,23,25-triene-3β-ol（1） and（19R,23E）-5/β,19-epoxy- 19-ethoxycucurbita-6,23-diene^3β,25-diol（2）,together with three known compounds,have been isolated from the fruit of Momordica charantia L.Their structures were determined on the basis of spectral analysis.Their cytotoxic activity was tested on 5 cancer cell lines,MCF-7,HepG2,Dul45,Colon205 and HL-60 by MTT assay.Compounds 1,3 and 4 showed weak cytotoxicity.

关 键 词：Momordica charantia L. Cucurbitane-type TRITERPENOID CYTOTOXICITY 

分 类 号：TQ464.2[化学工程—制药化工] S642.6[农业科学—蔬菜学]