微囊肿附属器癌一例  

Microcystic adnexal carcinoma： a case report

作　　者：姜祎群[1] 万川 吴建兵[1] 孙建方[1] 

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所,南京210042 [2]江西省皮肤病专科医院

出　　处：《国际皮肤性病学杂志》2011年第3期132-134,共3页International Journal of Dermatology and Venereology

摘　　要：患者女，43岁，左上唇皮肤斑块2年余。皮肤科检查：患者上唇左上方见一直径约2．5cm大小的斑块，肤色，表面毛细血管扩张，质硬，边界清楚。皮损组织病理检查：肿瘤位于真皮内，真皮上部可见多个导管结构和少数大的囊腔，真皮中下部可见上皮细胞条索，下部见角囊肿形成，肿瘤细胞侵犯神经和肌肉组织。免疫组化染色：肿瘤性上皮细胞成分细胞角蛋白均阳性，导管及腺腔结构上皮膜抗原阳性，S-100染色阳性的神经结构内可见细胞角蛋白阳性的上皮细胞成分浸润。诊断为微囊肿附属器癌。给予手术切除，目前仍在随访中。A case of microcystic adnexal carcinoma is reported. The patient was a 43-year-old female, who had presented with a plaque on the left upper lip for more than 2 years. Skin examination revealed a demarcated, skin-colored plaque measuring 2.5 cm in diameter with telangiectasia on the surface of the left upper lip. Skin biopsy showed that the tumor lied in the dennis, inf＇fltrating deeply into the underlying nervous and muscle tissue. There were many ductal structures and a small number of ramified glands with apocrine features in the upper dennis, strands of basophilic epithelial component imbedded in a markedly hyalinized stroma in the mid and lower dermis, as well as small and round keratinous cysts in the lower dennis. Immunohistochemistry revealed strong positive staining of the epithelial components with eytokeratin. The staining for CEA and epithelial membrane antigen （EMA） was noted in the superficial ducts and glands. S-100 stain showed the infiltration of peripheral nerve with cytokeratin-positive epithelial components. A diagnosis of microcystic adnexal carcinoma was made. The patient underwent an excisional surgery and was followed up.

关 键 词：癌 皮肤附件 汗腺肿瘤 少见病 

分 类 号：R739.5[医药卫生—肿瘤]